PMID: 2497268May 1, 1989Paper

Starvation leads to decreased levels of mRNA for myofibrillar proteins

The Journal of Surgical Research
Y FongS F Lowry

Abstract

Malnutrition is a common complicating factor in surgical illness. To investigate the cellular changes and mechanisms responsible for the protein wasting associated with nutritional deprivation, Sprague-Dawley rats were subjected to total protein-calorie starvation for 3 (n = 12) or 5 days (n = 12) and compared to freely fed animals monitored for 3 (n = 8) or 5 (n = 8) days. Gastrocnemius protein and RNA content and levels of mRNA coding for the myofibrillar proteins myosin heavy chain, myosin light chain, and alpha-actin were measured. Starvation resulted in a significant decrease in gastrocnemius mass and protein content, and was associated with decreases in mRNA levels for the three myofibrillar proteins assayed. We conclude that changes in mRNA levels for these proteins likely contribute to the loss of peripheral protein which occurs during total nutritional deprivation. In addition, the changes in mRNA levels for these three structural proteins appear to be coordinate, suggesting that transcription of no single myofibrillar protein is rate-limiting in the regulation of skeletal muscle protein content.

References

Aug 1, 1976·The American Journal of Physiology·J B Li, A L Goldberg
Nov 1, 1988·JPEN. Journal of Parenteral and Enteral Nutrition·Y FongA Cerami
Apr 1, 1987·The Journal of Surgical Research·B W WarnerJ E Fischer
Aug 1, 1987·The American Journal of Physiology·P R MorrisonF W Booth
Oct 1, 1987·The Journal of Surgical Research·J WernermanE Vinnars
Nov 11, 1974·JAMA : the Journal of the American Medical Association·B R BistrianR Heddle
Nov 28, 1967·Biochimica Et Biophysica Acta·J C Gan, H Jeffay
Jan 1, 1984·Annual Review of Biochemistry·W F Harrington, M E Rodgers
Jun 1, 1980·European Journal of Biochemistry·C Auffray, F Rougeon
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R M MedfordB Nadal-Ginard
Oct 1, 1982·The Biochemical Journal·T D BoyerD A Vessey

❮ Previous
Next ❯

Citations

Jan 1, 1992·Dysphagia·M S Veldee, L D Peth
Nov 1, 1995·The International Journal of Biochemistry & Cell Biology·H I Kim, I K Park
May 1, 1996·The International Journal of Biochemistry & Cell Biology·D C MacallanG E Griffin
Jan 30, 1999·The International Journal of Biochemistry & Cell Biology·J Y Kim, I K Park
Mar 29, 2000·The International Journal of Biochemistry & Cell Biology·Y C YangI K Park
Jun 27, 2000·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·W WangE Svanberg
Sep 1, 1992·JPEN. Journal of Parenteral and Enteral Nutrition·Y FongS F Lowry
Nov 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R Thomas JagoeAlfred L Goldberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.