STAT-3-independent production of IL-17 by mouse innate-like αβ T cells controls ocular infection

The Journal of Experimental Medicine
Anthony J St LegerRachel R Caspi

Abstract

Appropriate regulation of IL-17 production in the host can mean the difference between effective control of pathogens and uncontrolled inflammation that causes tissue damage. Investigation of conventional CD4+ T cells (Th17 cells) has yielded invaluable insights into IL-17 function and its regulation. More recently, we and others reported production of IL-17 from innate αβ+ T cell populations, which was shown to occur primarily via IL-23R signaling through the transcription factor STAT-3. In our current study, we identify promyelocytic leukemia zinc finger (PLZF)-expressing iNKT, CD4-/CD8+, and CD4-/CD8- (DN) αβ+T cells, which produce IL-17 in response to TCR and IL-1 receptor ligation independently of STAT-3 signaling. Notably, this noncanonical pathway of IL-17 production may be important in mucosal defense and is by itself sufficient to control pathogenic Staphylococcus aureus infection at the ocular surface.

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Citations

Aug 16, 2018·Clinical Reviews in Allergy & Immunology·Andrew Blauvelt, Andrea Chiricozzi
Sep 27, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Huiming ShengVipin Kumar
Aug 6, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·D Alejandro CanariaMatthew R Olson
Dec 8, 2021·Proceedings of the National Academy of Sciences of the United States of America·Muhammad S AlamJonathan D Ashwell

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Datasets Mentioned

BETA
SR41884

Methods Mentioned

BETA
flow cytometry
ELISA
FACS

Software Mentioned

GraphPad Prism
MACS Quant Analyzer
Tree Star
FlowJo
GraphPad

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