PMID: 9547277Jun 20, 1998Paper

STAT 5 and NF-Y are involved in expression and growth hormone-mediated sexually dimorphic regulation of cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase

Nucleic Acids Research
A SubramanianG Gil

Abstract

The level of expression of a number of sexually differentiated liver proteins is primarily determined by plasma growth hormone (GH). Adult males have a pulsatile profile of GH release, while females have a relatively steady-state pattern of GH release. An important subset of these sexually differentiated hepatic proteins is certain cytochrome P450s (P450s). CYP3A10/6beta-hydroxylase is a male-specific P450 that catalyzes 6beta-hydroxylation of lithocholic acid, and the pattern of GH secretion is directly responsible for male-specific expression of this gene. The DNA element involved in GH-mediated regulation of CYP3A10/6beta-hydroxylase promoter activity binds a member of the STAT (signal transducers and activators of transcription) family of proteins. In this study we functionally demonstrate that two members of the STAT family, STAT 5a and STAT 5b, mediate GH-dependent regulation of CYP3A10/6beta-hydroxylase promoter activity. Furthermore, a neighboring DNA element binds NF-Y, a transcription factor involved in maintaining high levels of transcription of many genes and known to functionally interact with other factors. In the CYP3A10/6beta-hydroxylase gene, NF-Y also modulates binding of STAT 5, thereby modulating GH-mediated...Continue Reading

References

Apr 1, 1989·Trends in Pharmacological Sciences·P G ZaphiropoulosJ A Gustafsson
Jan 1, 1983·Annual Review of Physiology·A K Roy, B Chatterjee
Sep 15, 1995·The Journal of Biological Chemistry·S M JacksonP A Edwards
Apr 21, 1995·The Journal of Biological Chemistry·T J WoodL A Haldosén
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·J EricssonP A Edwards
Aug 16, 1996·The Journal of Biological Chemistry·B C XuJ J Kopchick
Aug 16, 1996·The Journal of Biological Chemistry·T M KlauckS Jaken
Jun 1, 1996·Molecular Endocrinology·E D GalsgaardN Billestrup
Jan 1, 1996·Annual Review of Physiology·C Carter-SuL S Smit
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·G B UdyH W Davey

❮ Previous
Next ❯

Citations

May 24, 2005·Matrix Biology : Journal of the International Society for Matrix Biology·David C ColterDavid G Stokes
Sep 13, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·H K Choi, D J Waxman
Apr 1, 2000·Cytokine & Growth Factor Reviews·P M GrimleyH Rui
Jul 29, 2011·Annals of the New York Academy of Sciences·Myunggi BaikLothar Hennighausen
Jun 26, 2013·Biochemical and Biophysical Research Communications·Kosuke SaitoE James Squires
Nov 13, 2004·The Journal of Biological Chemistry·Christopher A Wiwi, David J Waxman
Mar 18, 2006·Molecular Endocrinology·David J Waxman, Caitlin O'Connor
Oct 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Craig A JaffePaul B Watkins
Apr 25, 2000·Archives of Biochemistry and Biophysics·T SakumaN Nemoto
Jun 21, 2001·Archives of Biochemistry and Biophysics·J J Potter, E Mezey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.