STAT 5a expression in the breast is maintained in secretory carcinoma, in contrast to other histologic types

Human Pathology
Brian L StraussF A Tavassoli

Abstract

The 7 signal transducer and activator of transcription (STAT) molecules are responsible for the transcription of a variety of regulatory and differentiation proteins. STAT 5a is activated through a variety of mechanisms; in the breast, this is predominantly through binding of prolactin to its receptor. Previously, we showed that STAT 5a expression is decreased in atypical and malignant breast ductal epithelial cells. Interestingly, STAT 5a overexpression was observed in cells undergoing secretory change. In this study, secretory carcinomas were examined by immunohistochemistry for the presence of STAT 5a. In contrast to usual in situ or invasive ductal carcinoma, which lacked STAT 5a expression, all secretory carcinomas (11 invasive and 7 in situ, including 4 cases with both) expressed STAT 5a. No expression was seen in apocrine metaplasia or in other specialized breast carcinomas, such as mucinous or clear cell carcinoma. This retention of signal in the secretory carcinomas may be explained by the higher STAT 5a concentration present in cells undergoing secretory changes in general. Alternatively, STAT 5a expression may be related to the t(12;15)(p13;q25) chromosomal translocation, associated with certain pediatric tumors and ...Continue Reading

References

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Jun 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marja T NevalainenHallgeir Rui
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Dec 21, 2004·Breast Cancer Research and Treatment·Liang ShanElizabeth G Snyderwine
Sep 1, 2005·Virchows Archiv : an International Journal of Pathology·Gary L BratthauerFattaneh A Tavassoli

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Citations

Jun 9, 2009·Current Problems in Surgery·Kristin L CoxV Suzanne Klimberg
May 27, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Gregor KringsYunn-Yi Chen
Jan 30, 2008·Journal of Mammary Gland Biology and Neoplasia·Kay-Uwe Wagner, Hallgeir Rui
Aug 25, 2019·Diagnostic Pathology·Ying YangLiu Liu

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