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STAT pathway activation limits the Ascl1-mediated chromatin remodeling required for neural regeneration from Muller glia in adult mouse retina.

bioRxiv

Sep 3, 2019

Thomas Andrew RehFred Rieke

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Abstract

Muller glia (MG) can serve as a source for retinal regeneration in some non-mammalian vertebrates. Recently we found that this process can be induced in mouse MG after injury, by combining transgenic expression of the proneural transcription factor Ascl1 and the HDAC inhibitor TSA. Howe...read more

Mentioned in this Paper

Deoxyribonucleases
Laboratory mice
Myasthenia Gravis
Nerve Regeneration
Neuroglia
Neurons
Retina
Stem Cells
Transcription Factor
ASCL1 protein, human
4
1
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STAT pathway activation limits the Ascl1-mediated chromatin remodeling required for neural regeneration from Muller glia in adult mouse retina.

bioRxiv

Sep 3, 2019

Thomas Andrew RehFred Rieke

DOI: 10.1101/753483

Abstract

Muller glia (MG) can serve as a source for retinal regeneration in some non-mammalian vertebrates. Recently we found that this process can be induced in mouse MG after injury, by combining transgenic expression of the proneural transcription factor Ascl1 and the HDAC inhibitor TSA. Howe...read more

Mentioned in this Paper

Deoxyribonucleases
Laboratory mice
Myasthenia Gravis
Nerve Regeneration
Neuroglia
4
1

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