STAT1 is inactivated by a caspase.

The Journal of Biological Chemistry
P King, S Goodbourn

Abstract

Apoptosis involves the activation of a cascade of interleukin-1beta converting enzyme-like proteases (caspases), a group of cysteine proteases related to the prototype interleukin-1beta-converting enzyme (caspase-1). These proteases cleave specific intracellular targets such as poly(ADP-ribose) polymerase, DNA-dependent protein kinase, and nuclear lamins. We show here that apoptosis can be induced by double-stranded RNA. The induction of apoptosis by double-stranded RNA and other agents leads to the cleavage by a caspase of the signal transducer and activator of transcription factor, STAT1 which is pivotal in the signal transduction pathways of the interferons and many other cytokines and growth factors. The product of this cleavage is no longer able to mediate interferon-activated signal transduction and the cleavage event may play a role in regulating the apoptosis response itself.

References

Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·R McKendryG R Stark
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·L E ReidI M Kerr
Sep 1, 1982·Molecular and Cellular Biology·C M GormanB H Howard
Feb 17, 1995·The Journal of Biological Chemistry·M Tewari, V M Dixit
Jan 1, 1995·Annual Review of Biochemistry·C Schindler, J E Darnell
Nov 1, 1995·The Journal of General Virology·I MoriY Kimura
Nov 1, 1994·Current Biology : CB·J BriscoeM Müller
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·A KumarB R Williams
Aug 1, 1994·Molecular and Cellular Biology·R J Clem, L K Miller
Jun 1, 1994·Journal of Virology·V S HinshawD Evans
Mar 1, 1993·Immunology Today·J SavillC Haslett
Sep 10, 1993·Cell·L A TartagliaD V Goeddel
Jun 14, 1996·Cell·A Fraser, G Evan
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·T Fernandes-AlnemriE S Alnemri
Feb 1, 1996·Current Opinion in Genetics & Development·A Takahashi, W C Earnshaw
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·M C YeungA S Lau
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·J Lotem, L Sachs
Oct 15, 1996·Nucleic Acids Research·B A EldadahA I Faden
Jan 2, 1997·Nature·H Duan, V M Dixit

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Citations

Sep 24, 1999·Journal of Neuroscience Research·S L Chan, M P Mattson
Feb 19, 2000·Journal of Cellular Biochemistry·C Avivi-GreenB Schwartz
Mar 14, 2007·Immunogenetics·Laura M TennantPenny P Powell
Jun 14, 2005·Molecular Immunology·Laurent SabbaghLuchino Y Cohen
Aug 24, 1999·Neurochemistry International·N Marks, M J Berg
Apr 5, 2001·Biochimica Et Biophysica Acta·M BarkettT D Gilmore
Dec 11, 2002·Current Opinion in Cell Biology·Alicia Algeciras-SchimnichMarcus E Peter
Aug 5, 1999·The Biochemical Journal·S SatohK Shimotohno
Mar 26, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jun Chen, Louie Naumovski
Jun 12, 2003·Nucleic Acids Research·Kay S Childs, Stephen Goodbourn
Feb 10, 2000·Annals of the New York Academy of Sciences·D K Miller
Jan 19, 2007·Journal of Virology·Jean-Baptiste MarqDominique Garcin
Jul 23, 2002·Journal of Virology·Friedemann WeberRichard M Elliott
Jan 29, 2003·Journal of Virology·Kathrin HagmaierGeorg Kochs
Jun 29, 2000·Annual Review of Biochemistry·W C EarnshawS H Kaufmann
Jun 8, 1999·Annual Review of Immunology·J C Rathmell, C B Thompson
Dec 17, 2004·Journal of Cellular and Molecular Medicine·A Stephanou
Jan 30, 2004·International Journal of Experimental Pathology·Anastasis Stephanou, David S Latchman
May 24, 2008·Obesity·Fang HeJacqueline M Stephens
Apr 1, 2012·JAK-STAT·Richard A KnightAnastasis Stephanou
Oct 31, 2003·Virology·Jessica A ShafferPaul A Rota
May 20, 2004·The Journal of Biological Chemistry·Daniel ThomasFriedemann Weber

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