STAT1 Signaling within Macrophages Is Required for Antifungal Activity against Cryptococcus neoformans

Infection and Immunity
Chrissy M Leopold WagerFloyd L Wormley

Abstract

Cryptococcus neoformans, the predominant etiological agent of cryptococcosis, is an opportunistic fungal pathogen that primarily affects AIDS patients and patients undergoing immunosuppressive therapy. In immunocompromised individuals, C. neoformans can lead to life-threatening meningoencephalitis. Studies using a virulent strain of C. neoformans engineered to produce gamma interferon (IFN-γ), denoted H99γ, demonstrated that protection against pulmonary C. neoformans infection is associated with the generation of a T helper 1 (Th1)-type immune response and signal transducer and activator of transcription 1 (STAT1)-mediated classical (M1) macrophage activation. However, the critical mechanism by which M1 macrophages mediate their anti-C. neoformans activity remains unknown. The current studies demonstrate that infection with C. neoformans strain H99γ in mice with macrophage-specific STAT1 ablation resulted in severely increased inflammation of the pulmonary tissue, a dysregulated Th1/Th2-type immune response, increased fungal burden, deficient M1 macrophage activation, and loss of protection. STAT1-deficient macrophages produced significantly less nitric oxide (NO) than STAT1-sufficient macrophages, correlating with an inability...Continue Reading

References

Jan 1, 1990·The Journal of Clinical Investigation·D L GrangerD T Durack
Sep 21, 1989·The New England Journal of Medicine·S L Chuck, M A Sande
Apr 1, 1988·The Journal of Infectious Diseases·W E Dismukes
Apr 1, 1988·The Journal of Clinical Investigation·D L GrangerD T Durack
Oct 1, 1985·Annals of Internal Medicine·J A KovacsG Overturf
Feb 1, 1974·Annals of Internal Medicine·R D Diamond, J E Bennett
Sep 1, 1972·The American Journal of Medicine·J L Lewis, S Rabinovich
Jul 1, 1995·American Journal of Respiratory Cell and Molecular Biology·J A LovchikM F Lipscomb
Oct 1, 1995·Clinical Microbiology Reviews·T G Mitchell, J R Perfect
Jan 23, 1999·The American Journal of Pathology·F FacchettiR Badolato
Mar 4, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J AbadiL Pirofski
Jan 6, 2000·Transgenic Research·B E ClausenI Förster
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T R TraynorG B Huffnagle
Aug 16, 2001·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·John R. Perfect, Gary M. Cox
Nov 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M HesseT A Wynn
Jun 5, 2003·European Journal of Immunology·Aron J MednickArturo Casadevall
Nov 1, 1956·American Journal of Clinical Pathology·J D KEYE, W E MAGEE
Jan 1, 1962·Annals of Internal Medicine·E GOLDSTEIN, O N RAMBO
Nov 15, 2003·Current Biology : CB·Marisol de Jesús-BerríosJoseph Heitman
Sep 1, 1950·The American Journal of Medicine·B R GENDELS L NORMAN
Dec 25, 2004·Infection and Immunity·Ryan M KellyStuart M Levitz
Jan 7, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yadira HernandezGary B Huffnagle
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shikha AroraGary B Huffnagle
May 24, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nina SinghUNKNOWN Cryptococcal Collaborative Transplant Study Group
Jul 26, 2005·Infection and Immunity·F L WormleyG M Cox
Jul 27, 2006·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Hiromi TakakiTakashi Kobayashi
Sep 12, 2006·Eukaryotic Cell·Steven S GilesJohn R Perfect
Oct 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Tae-Young RohKeji Zhao
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Uwe MüllerGottfried Alber
Nov 26, 2008·Nature Reviews. Immunology·David M Mosser, Justin P Edwards

❮ Previous
Next ❯

Citations

Jun 19, 2015·PLoS Pathogens·Chrissy M Leopold Wager, Floyd L Wormley
May 20, 2017·Nature Reviews. Neurology·Xi LanJian Wang
Jan 10, 2018·Infection and Immunity·Patricia F HerkertLeo A B Joosten
Mar 10, 2018·Journal of Fungi·Althea Campuzano, Floyd L Wormley
Jun 16, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lori M NealMichal A Olszewski
Jan 11, 2018·Journal of Cellular Physiology·Abbas Shapouri-MoghaddamAmirhossein Sahebkar
Jun 3, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carlos M De Leon-RodriguezArturo Casadevall
Aug 12, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Seagal Teitz-TennenbaumJohn J Osterholzer
Aug 1, 2019·European Journal of Immunology·Samira Salek-ArdakaniTracy Hussell
Feb 28, 2016·The Journal of Microbiology·Camaron Hole, Floyd L Wormley
Feb 19, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mingzheng LiHuipin Yuan
Jun 21, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ko SatoKazuyoshi Kawakami
Sep 30, 2020·PloS One·Daniel BodmerSoledad Levano Huaman
Sep 25, 2017·Journal of Fungi·Lena J Heung
Jun 8, 2018·Medical Mycology·Donald L Granger, Donna M Call
Jul 6, 2019·Nature Communications·Camaron R HoleFloyd L Wormley
Mar 3, 2020·Frontiers in Cellular and Infection Microbiology·Benjamin N NelsonKaren L Wozniak
Nov 23, 2017·Frontiers in Immunology·Marley C Caballero Van DykeFloyd L Wormley
Jan 21, 2017·PloS One·Althea CampuzanoFloyd L Wormley
Jun 1, 2018·Cellular & Molecular Biology Letters·Aixia SunJian Zhang
Jan 29, 2019·Frontiers in Immunology·Zayda L Piedra-QuinteroLeopoldo Santos-Argumedo
Nov 7, 2017·Trends in Microbiology·Marley C Caballero Van Dyke, Floyd L Wormley
May 22, 2021·Frontiers in Pharmacology·Xiaoxiao ZhuXia Li
Oct 18, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hor-Yue TanYibin Feng
Jul 24, 2021·European Journal of Pharmacology·Anusha GovindulaJayesh Mudgal
Sep 5, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kristie D GoughenourMichal A Olszewski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here