STAT3: a critical component in the response to Helicobacter pylori infection

Cellular Microbiology
T R MenheniottAndrew S Giraud

Abstract

STAT3 imparts a profound influence on both the epithelial and immune components of the gastric mucosa, and through regulation of key intracellular signal transduction events, is well placed to control inflammatory and oncogenic outcomes in the context of Helicobacter (H.) pylori infection. Here we review the roles of STAT3 in the host immune response to H. pylori infection, from both gastric mucosal and systemic perspectives, as well as alluding more specifically to STAT3-dependent mechanisms that might be exploited as drug targets.

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Citations

Dec 7, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jon N BuzzelliTrevelyan R Menheniott
Mar 4, 2020·Oncogene·Yanan ZhaoWei Kang
Aug 11, 2020·Journal of Immunology Research·Siru Nie, Yuan Yuan
Jan 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yong-Sheng TengYuan Zhuang

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