Stat3 inhibitor abrogates the expression of PD-1 ligands on lymphoma cell lines

Journal of Clinical and Experimental Hematopathology : JCEH
Chaoya MaYoshihiro Komohara

Abstract

Recent studies have indicated the significance of immune checkpoint molecules including programmed death-1 (PD-1), cytotoxic T-lymphocyte associated protein 4, and T-cell immunoglobulin and mucin domain-containing molecule-3 for anti-tumor immune responses. We previously investigated PD-1 ligand 1/2 (PD-L1/2) expression in lymphoma cell lines, and found that PD-L1/2 is expressed on the adult T-cell leukemia/lymphoma (ATL-T) and B-cell lymphoma (SLVL) cell lines. In the present study, we investigated whether the Stat3 inhibitor WP1066 abrogated PD-L1/2 expression in lymphoma cell lines. Incubation with WP1066 inhibited lymphoma cell growth and induced cell apoptosis. PD-L1/2 expression in the ATL-T, SLVL, and human brain malignant lymphoma (HKBML) cell lines was significantly abrogated by WP1066 treatment. These data indicated that a Stat3 inhibitor abrogated PD-L1/2 expression in lymphoma cells. Such an inhibitor is therefore considered to be useful for additional immunotherapy in patients with advanced lymphoma.

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Citations

Mar 28, 2018·Journal of Hematology & Oncology·Rosemarie Tremblay-LeMayHong Chang
Mar 9, 2018·Blood·Stephanie C CaseyDean W Felsher
Dec 14, 2018·Journal of Clinical and Experimental Hematopathology : JCEH·Yoshihiro KomoharaShinya Suzu
Nov 22, 2018·Journal of Translational Medicine·Hyun Jung KwonJin Ho Paik
Nov 7, 2019·Journal of Cellular Biochemistry·Tiesuo ZhaoZhiwei Feng
Sep 21, 2018·Cancers·Teresa PoggioAnna L Illert
Apr 17, 2018·Journal of Clinical and Experimental Hematopathology : JCEH·Yoshihiko OkamuraYasuhiro Hayashi
Nov 12, 2019·Journal of Clinical and Experimental Hematopathology : JCEH·Yoshihiro Komohara, Mamoru Harada
Apr 11, 2018·Therapeutic Advances in Medical Oncology·Ilaria AttiliRafael Rosell
Dec 6, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Guoliang QiaoHerbert Kim Lyerly

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