Abstract
Signal transducer and activator of transcription (STAT) 3 is the main mediator of IL-6-type cytokine signaling and an important transcriptional regulator of cell proliferation, maturation and survival. It has been described as a key player in cancer development and progression. However, under certain circumstances, STAT3 is also considered a potent tumor suppressor. This heterogeneity partially depends on its expression as different isoforms. Alternative splicing gives rise to two STAT3 isoforms, STAT3α and its truncated version STAT3β. Both isoforms are transcriptionally active and display distinct functions under physiological and pathological conditions. In fact, while STAT3α is widely described as an oncogene, STAT3β has gained attention as a potential tumor suppressor. This review provides a concise overview of the current knowledge on STAT3 during tumorigenesis, with special emphasis on the unique and complex roles of its alternatively spliced isoforms.
Citations
Jun 21, 2019·Current Topics in Medicinal Chemistry·Yang Sheng HuXin Hua Liu
Dec 22, 2019·Cancers·Fen ZhuLixin Rui
Jan 11, 2020·International Journal of Oncology·Zhong HongHui Chen
Sep 20, 2020·Journal of Cellular and Molecular Medicine·Inbal ShamirYael Nevo-Caspi
Sep 3, 2020·Cancers·Ping-Lian YangLi-Yan Xu
May 14, 2019·International Journal of Oncology·Young-Lan ParkYoung-Eun Joo
Oct 12, 2019·Cells·Sara Rodríguez-EnríquezRafael Moreno-Sánchez
May 6, 2020·Cancers·Julian MohrherrEmilio Casanova
Dec 24, 2018·Nature Reviews. Cancer·Jennifer HuynhMatthias Ernst
Sep 21, 2018·International Journal of Molecular Sciences·Lidia Avalle, Valeria Poli
Oct 13, 2020·Frontiers in Immunology·Katrin MeisslBirgit Strobl
Jan 1, 2021·Cell Proliferation·Yun LiuJiake Xu
Nov 13, 2019·Seminars in Cancer Biology·Pathum S ThilakasiriAshwini L Chand
Nov 30, 2019·World Neurosurgery·Xueliang YangYuanbo Liu
Apr 24, 2020·Seminars in Cancer Biology·Chakrabhavi Dhananjaya MohanKanchugarakoppal S Rangappa
Mar 7, 2021·Cancers·Zhen-Yuan ZhengLi-Yan Xu
Apr 6, 2021·Frontiers in Cell and Developmental Biology·Xiangru HuangLingyong Jiang
Apr 15, 2021·Nutrition & Metabolism·Huimin LiuGuoqing Yang
Apr 23, 2021·Journal of Cellular Physiology·Wangrui LeiYang Yang
Jun 3, 2021·Biomedicines·Julia Peñas-MartínezIrene Martínez-Martínez