PMID: 15223824Jun 30, 2004Paper

STAT3-mediated signaling in the determination of rod photoreceptor cell fate in mouse retina

Investigative Ophthalmology & Visual Science
Samuel Shao-Min ZhangXin-Yuan Fu

Abstract

The purpose of this study was to determine the intracellular pathways by which ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF) negatively regulate the development of rod photoreceptors in the mouse retina. Retina explant cultures derived from timed-pregnant CD-1 mice were used to monitor rod photoreceptor differentiation. CNTF was used to activate the signal transducer and activator of transcription (STAT)-3 and mitogen-activated protein kinase (MAPK) signal transduction pathways. Activation of STAT3 and MAPK were manipulated by using dominant-negative STAT3 recombinant adenoviruses and a specific inhibitor of MAPK, respectively. Explanted retinas were harvested at distinct time points and processed for immunohistochemistry. Blocking of the MAPK pathway by the MAPK inhibitor PD98059 did not affect normal development of rods in retina explants or the suppression of their appearance by treatment with CNTF. In contrast, activated STAT3 was necessary for suppression of the rod cell fate decision. A deficiency of the STAT3 pathway induced by a dominant negative STAT3 abolished inhibition of rod development by CNTF. These results indicate that STAT3, but not MAPK, can critically regulate photoreceptor developm...Continue Reading

Citations

Dec 18, 2007·Histochemistry and Cell Biology·David MaerkerMonika Wimmer
Jan 15, 2010·Journal of Ocular Biology, Diseases, and Informatics·Mu-Gen LiuSamuel Shao-Min Zhang
Dec 1, 2010·Journal of Ocular Biology, Diseases, and Informatics·Samuel Shao-Min ZhangColin J Barnstable
Jun 28, 2005·Experimental Eye Research·Samuel Shao-Min ZhangColin J Barnstable
Dec 16, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carolina Pinzon-GuzmanColin J Barnstable
May 13, 2008·Experimental Eye Research·Chun ZhangSamuel Shao-Min Zhang
Aug 22, 2006·Biochemical and Biophysical Research Communications·Leiling ChenJoyce Tombran-Tink
Jul 7, 2007·Expert Opinion on Therapeutic Targets·Hongwei Gao, Peter A Ward
Aug 18, 2006·Developmental Biology·Jérôme RogerOlivier Goureau
Jan 3, 2007·Developmental Biology·Yoko OzawaHideyuki Okano
Feb 3, 2009·Neuron·Akishi OnishiSeth Blackshaw
Aug 12, 2014·Journal of Molecular Neuroscience : MN·Carolina Pinzon-GuzmanColin J Barnstable
Sep 18, 2007·Journal of Neural Engineering·Ingela Liljekvist-Larsson, Kjell Johansson
Feb 5, 2019·Molecular Neurobiology·Amy Q Lu, Colin J Barnstable
Dec 1, 2019·The Journal of Comparative Neurology·Zeinab Amini-Farsani, Samira Asgharzade
Oct 27, 2018·Frontiers in Cell and Developmental Biology·Tiaosi XingColin J Barnstable
Aug 7, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Meijing WangDaniel R Meldrum
Feb 15, 2017·Stem Cells International·Krista M BeachDeborah C Otteson
Nov 21, 2021·Experimental & Molecular Medicine·Yohei TomitaZhongjie Fu

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