STAT3, p38 MAPK, and NF-kappaB drive unopposed monocyte-dependent fibroblast MMP-1 secretion in tuberculosis.

American Journal of Respiratory Cell and Molecular Biology
Cecilia M O'KaneJon S Friedland

Abstract

Tissue destruction characterizes infection with Mycobacterium tuberculosis (Mtb). Type I collagen provides the lung's tensile strength, is extremely resistant to degradation, but is cleaved by matrix metalloproteinase (MMP)-1. Fibroblasts potentially secrete quantitatively more MMP-1 than other lung cells. We investigated mechanisms regulating Mtb-induced collagenolytic activity in fibroblasts in vitro and in patients. Lung fibroblasts were stimulated with conditioned media from Mtb-infected monocytes (CoMTb). CoMTb induced sustained increased MMP-1 (74 versus 16 ng/ml) and decreased tissue inhibitor of metalloproteinase (TIMP)-1 (8.6 versus 22.3 ng/ml) protein secretion. CoMTb induced a 2.7-fold increase in MMP-1 promoter activation and a 2.5-fold reduction in TIMP-1 promoter activation at 24 hours (P = 0.01). Consistent with this, TIMP-1 did not co-localize with fibroblasts in patient granulomas. MMP-1 up-regulation and TIMP-1 down-regulation were p38 (but not extracellular signal-regulated kinase or c-Jun N-terminal kinase) mitogen-activated protein kinase-dependent. STAT3 phosphorylation was detected in fibroblasts in vitro and in tuberculous granulomas. STAT3 inhibition reduced fibroblast MMP-1 secretion by 60% (P = 0.046)...Continue Reading

References

Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y ZhangW N Rom
Dec 1, 1993·The Journal of Experimental Medicine·A M CooperI M Orme
Sep 22, 2000·The Biochemical Journal·S P DaviesP Cohen
Dec 6, 2000·The Journal of Experimental Medicine·Z WangJ A Elias
Mar 20, 2001·American Journal of Respiratory and Critical Care Medicine·K ImaiJ D'Armiento
Aug 14, 2001·Infection and Immunity·M Quiding-JärbrinkG J Bancroft
Aug 9, 2002·The European Respiratory Journal·L ZhengK W Tsang
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael H PillingerSteven B Abramson
Nov 26, 2003·Infection and Immunity·Gilla KaplanLinda-Gail Bekker
May 1, 2004·The Journal of Biological Chemistry·Melissa I WickremasingheJon S Friedland
Sep 6, 2005·American Journal of Respiratory and Critical Care Medicine·Paul T G ElkingtonJon S Friedland
Sep 24, 2005·Clinical and Experimental Immunology·P T G ElkingtonJ S Friedland
Oct 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul T G ElkingtonJon S Friedland
Dec 13, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·James E HarrisJon S Friedland
Mar 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cecilia M O'KaneJon S Friedland
Oct 10, 2008·Respiration; International Review of Thoracic Diseases·Georgina González-AvilaM Carmen Sarabia

❮ Previous
Next ❯

Citations

May 15, 2013·Bulletin of Experimental Biology and Medicine·D V SumenkovaL E Panin
Apr 10, 2014·American Journal of Respiratory and Critical Care Medicine·Catherine W M OngJon S Friedland
Oct 3, 2014·Experimental Lung Research·Ana G Ramos-MartínezCarmen J Serrano
Sep 3, 2014·BMC Microbiology·Andréia Pacheco de SouzaRoberto Meyer
Mar 15, 2016·Journal of Natural Products·Hum Nath JnawaliYangmee Kim
Jun 19, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Anita R IskandarJulia Hoeng
Sep 22, 2015·Journal of Ethnopharmacology·Narisara TiraravesitJarupa Viyoch
May 23, 2012·Current Opinion in Immunology·Andrea M Cooper, Egidio Torrado
Mar 25, 2015·Immunology and Cell Biology·Philippa J RandallMuazzam Jacobs
Apr 11, 2014·The Lancet. Respiratory Medicine·Stefan H E KaufmannMarkus Maeurer
Jan 25, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dasom JeonYangmee Kim
Feb 23, 2017·Molecular and Cellular Endocrinology·Rong LuJun Sun
Dec 3, 2014·Seminars in Immunology·Martin E Rottenberg, Berit Carow
Mar 21, 2018·Bioscience Reports·Eugenia RoupakiaEvangelos Kolettas
Jul 20, 2019·Cells·Moon-Chang ChoiYoonkyung Park
Jan 1, 2014·Journal of Cellular and Molecular Medicine·Yurong FuRuifang Li
Nov 7, 2019·American Journal of Industrial Medicine·Kaio Cezar Rodrigues SalumFabiana Barzotto Kohlrausch
Oct 1, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shivani SinghJon S Friedland
Aug 28, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hong-Sheng LeeChien-Huang Lin
Jun 20, 2020·Antioxidants & Redox Signaling·Eduardo P AmaralBruno B Andrade
Dec 7, 2017·The Journal of Pathology·Shivani SinghJon S Friedland
May 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Justin A GreenJon S Friedland
Sep 3, 2019·Frontiers in Immunology·Jianjun WangRodolfo C Garcia
Jun 8, 2021·Frontiers in Immunology·Daniela E KirwanJon S Friedland

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.