STAT3‑regulated long non‑coding RNAs lnc‑7SK and lnc‑IGF2‑AS promote hepatitis C virus replication

Molecular Medicine Reports
Yulin XiongXiaohong Wang

Abstract

Long non‑coding RNAs (lncRNAs) are a class of RNAs that do not code protein but are important in diverse biological processes. In previous years, with the application of high‑throughput sequencing, a large number of lncRNAs associated with virus infections have been identified and intensively investigated, however, there are few studies examining the association between lncRNAs and HCV replication. Previous studies have demonstrated that signal transducer and activator of transcription 3 (STAT3) is activated by the hepatitis C virus (HCV) and in turn increases the replication of HCV. However, the detailed molecular mechanism is only partially understood. In the present study, using human lncRNA polymerase chain reaction (PCR) arrays, it was identified that lnc‑IGF2‑AS, lnc‑7SK, lnc‑SChLAP1 and lnc‑SRA1 are upregulated by STAT3. In addition, among these four lncRNAs, only lnc‑IGF2‑AS and lnc‑7SK were involved in HCV replication. Transfection of siRNA lnc‑7SK and siRNA lnc‑IGF2‑AS partially inhibited the replication of HCV in Huh7 cells. Data also indicated that when transfected with siRNA lnc‑7SK and siRNA lnc‑IGF2‑AS, the expression of phosphatidylinositol 4‑phosphate (PI4P), which was identified to be associated with HCV repli...Continue Reading

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Citations

Oct 17, 2017·Frontiers in Microbiology·Marina Barriocanal, Puri Fortes
Jun 12, 2019·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Ju HuangBo Zhang
Mar 6, 2018·Frontiers in Microbiology·Saba Valadkhan, Puri Fortes
Aug 1, 2018·Future Virology·Zhangmei ChangJian-Er Long
Mar 28, 2020·International Journal of Molecular Sciences·Juan P Unfried, P Fortes
Feb 11, 2020·Taiwanese Journal of Obstetrics & Gynecology·Ai-Hua WuXue-Fang Liang
Jun 2, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Chakrabhavi Dhananjaya MohanKanchugarakoppal S Rangappa
Jul 30, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bing YanDesheng Yang
Aug 10, 2021·World Journal of Gastroenterology : WJG·Hui-Chun LiShih-Yen Lo

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Methods Mentioned

BETA
PCR
Profiler
electrophoresis
transfection

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