STAT4 rs7574865 G/T and PTPN22 rs2488457 G/C polymorphisms influence the risk of developing juvenile idiopathic arthritis in Han Chinese patients

PloS One
Zhi-Dan FanHai-Guo Yu

Abstract

Juvenile idiopathic arthritis (JIA) is a common autoimmune disease characterized by environmental influences along with several predisposing genes in the pathogenesis. The protein tyrosine phosphatase nonreceptor 22 (PTPN22) and signal transducer and activator of transcription factor 4 (STAT4) have been recognized as susceptibility genes for numerous autoimmune diseases. Associations of STAT4 rs7574865 G/T and PTPN22 (rs2488457 G/C and rs2476601 C/T) polymorphisms with JIA have repeatedly been replicated in several Caucasian populations. The aim of this study was to investigate the influence of three polymorphisms mentioned above on the risk of developing JIA in Han Chinese patients. Genotyping was performed on a total of 137 Chinese patients with JIA (JIA group) and 150 sex and age frequency-matched healthy volunteers (Control group). The single-nucleotide polymorphisms (SNP) were determined by using direct sequencing of PCR-amplified products. There were significant differences of PTPN22 rs2488457 G/C and STAT4 rs7574865 G/T polymorphisms between both groups. However, no significant difference was observed in distribution frequencies of PTPN22 rs2476601 polymorphism. The association with the PTPN22 rs2488457 G/C polymorphism ...Continue Reading

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Citations

Aug 26, 2015·Journal of Autoimmunity·Aimee O Hersh, Sampath Prahalad
Dec 7, 2018·Arthritis & Rheumatology·Tomas MustelinStephanie M Stanford
Jun 28, 2017·Rheumatology International·Liuh Ling GohUNKNOWN TTSH RA Study Group
Jun 18, 2017·Cold Spring Harbor Perspectives in Biology·George R StarkYuxin Wang
Jan 12, 2021·Frontiers in Cell and Developmental Biology·Patricia Castro-SanchezRose Zamoyska

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Methods Mentioned

BETA
PCR

Software Mentioned

SPSS
GeneMapper

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