STAT5 is critical to maintain effector CD8+ T cell responses.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Pulak TripathiDavid A Hildeman

Abstract

During an immune response, most effector T cells die, whereas some are maintained and become memory T cells. Factors controlling the survival of effector CD4(+) and CD8(+) T cells remain unclear. In this study, we assessed the role of IL-7, IL-15, and their common signal transducer, STAT5, in maintaining effector CD4(+) and CD8(+) T cell responses. Following viral infection, IL-15 was required to maintain a subpopulation of effector CD8(+) T cells expressing high levels of killer cell lectin-like receptor subfamily G, member 1 (KLRG1), and lower levels of CD127, whereas IL-7 and IL-15 acted together to maintain KLRG1(low)CD127(high) CD8(+) effector T cells. In contrast, effector CD4(+) T cell numbers were not affected by the individual or combined loss of IL-15 and IL-7. Both IL-7 and IL-15 drove phosphorylation of STAT5 within effector CD4(+) and CD8(+) T cells. When STAT5 was deleted during the course of infection, both KLRG1(high)CD127(low) and KLRG1(low)CD127(high) CD8(+) T cells were lost, although effector CD4(+) T cell populations were maintained. Furthermore, STAT5 was required to maintain expression of Bcl-2 in effector CD8(+), but not CD4(+), T cells. Finally, IL-7 and IL-15 required STAT5 to induce Bcl-2 expression a...Continue Reading

References

Nov 3, 1995·Science·T NosakaJ N Ihle
Dec 8, 1998·The Journal of Experimental Medicine·K ImadaW J Leonard
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·H H LeeG Cheng
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J D LordB H Nelson
Jan 3, 2001·Molecular and Cellular Biology·R WenJ L Cleveland
Jul 20, 2002·Science·Klaus OkkenhaugBart Vanhaesebroeck
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aaruni KhanolkarAllan J Zajac
Jul 1, 2004·Molecular and Cellular Biology·Qiong JiangScott K Durum
May 17, 2005·Nature Immunology·Zhengfan JiangBruce Beutler
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Toshiki YajimaYasunobu Yoshikai
Jan 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Zhengju YaoJohn J O'Shea
Jun 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Mark P RubinsteinJonathan Sprent
Jun 9, 2006·European Journal of Immunology·Sara WojciechowskiDavid A Hildeman
Dec 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoh-Ichi SekiMasato Kubo
Jan 30, 2007·Nature Reviews. Immunology·Renata Mazzucchelli, Scott K Durum
Feb 28, 2007·The Journal of Experimental Medicine·Lisa C OsborneNinan Abraham
Mar 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pulak TripathiDavid A Hildeman
Apr 11, 2007·The Journal of Experimental Medicine·Jared F PurtonCharles D Surh
Jun 27, 2007·The Journal of Experimental Medicine·Sara WojciechowskiDavid A Hildeman
Jul 5, 2007·Proceedings of the National Academy of Sciences of the United States of America·Timothy W HandSusan M Kaech
Jul 24, 2007·Current Opinion in Immunology·David HildemanPhilippa Marrack
Dec 19, 2007·Infection and Immunity·Stacie RecklingDavid Hildeman
Feb 5, 2008·The Journal of Clinical Investigation·Som G NanjappaM Suresh
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jodie S HaringJohn T Harty
Oct 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Martin Prlic, Michael J Bevan
Mar 10, 2009·Seminars in Immunology·Louise M D'CruzAnanda W Goldrath

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Citations

Apr 6, 2013·Cell Death and Differentiation·P TripathiD A Hildeman
Jan 25, 2012·The Journal of Experimental Medicine·Robert J JohnstonShane Crotty
Jun 28, 2012·Clinical & Developmental Immunology·Bo JinAnthony E T Yeo
Aug 16, 2014·Cell Death and Differentiation·S KurtulusD A Hildeman
Apr 18, 2018·Immunological Reviews·James L ReadingSergio A Quezada
Apr 18, 2018·Immunological Reviews·Maike HofmannRobert Thimme
Nov 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kun-Po LiDavid A Hildeman
Jun 20, 2014·Journal of Virology·Varun N KapoorRaymond M Welsh
Dec 5, 2014·Journal of Virology·Jenny W CheRaymond M Welsh
Nov 7, 2019·Cancers·Kelsey L PolakMark W Jackson
Dec 5, 2017·The Journal of Clinical Investigation·Ha Thi Thanh PhamRichard Moriggl
Feb 27, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Diana M Mitchell, Matthew A Williams
Jul 28, 2016·European Journal of Immunology·Pulak TripathiDavid A Hildeman
Apr 1, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sema KurtulusDavid A Hildeman
Jun 12, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pheh-Ping ChangCarola G Vinuesa
Apr 3, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eui Ho KimM Suresh
Apr 12, 2019·The Journal of Biological Chemistry·Paramita ChakrabortyShikhar Mehrotra
Sep 29, 2019·Cell Death and Differentiation·Kun-Po LiDavid A Hildeman
Apr 14, 2020·The Journal of Clinical Investigation·Darshana KadekarVasileios Bekiaris
Oct 11, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Olga M AntonEric O Long
Sep 17, 2016·The Journal of Biological Chemistry·Erik Allen Lykken, Qi-Jing Li
May 18, 2019·Medical Microbiology and Immunology·Yanjun FengEdward S Mocarski
Jun 23, 2019·Proceedings of the National Academy of Sciences of the United States of America·Rohit R JadhavJorg J Goronzy
Dec 12, 2018·American Journal of Clinical Dermatology·Helen He, Emma Guttman-Yassky
Mar 3, 2020·Cancer Immunology, Immunotherapy : CII·Diane L Costanzo-GarveyLeah M Cook
May 4, 2017·Immunological Reviews·Kun-Po LiDavid A Hildeman
Nov 27, 2019·Cancers·Grégory VerdeilNathalie Auphan-Anezin
Jul 14, 2020·Therapeutic Advances in Musculoskeletal Disease·Flavia SunziniStefan Siebert
Sep 4, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Akifumi AbeKoichi Ikuta
Oct 23, 2020·Journal of Clinical Immunology·Corinne L FoleyVivian Hwa
Oct 13, 2019·Seminars in Immunology·Mitra ShourianHélène Decaluwe

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