STAT6 correlates with response to immune checkpoint blockade therapy and predicts worse survival in thyroid cancer.

Biomarkers in Medicine
Li WangYing Hao

Abstract

Aim: The signal transducer and activator of transcription (STAT) family has been documented. However, the role of STATs in thyroid cancer was not fully studied. Materials & methods: A survival analysis of STATs was performed. The function modulated by STAT6 was examined. The role of STAT6 in cancer immune infiltrates and immune checkpoint blockade molecules was investigated. Results: Only low STAT6 expression correlated with worse survival. STAT6 is involved in cell cycle, cell adhesion, apoptosis and notch signaling pathways. STAT6 was significantly positively associated with immune infiltration of B cells, CD4+ T cells, neutrophils, macrophages, dendritic cells and the immune checkpoint blockade molecules programmed cell death-ligand 1, programmed cell death-ligand 2 and cytotoxic T-lymphocyte-associated protein 4. Conclusion: STAT6 may act as a prognostic biomarker and provide useful information for immunotherapy in thyroid carcinoma.

References

Sep 12, 1997·Science·J E Darnell
Oct 8, 2004·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·H SiavashJ J Sauk
Oct 29, 2004·The American Journal of Pathology·Charles V Clevenger
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Mar 17, 2006·Cytokine & Growth Factor Reviews·Daniel HebenstreitAlbert Duschl
Jan 30, 2009·Journal of Gastroenterology and Hepatology·Dae-Young KimSung-Pyo Hong
Mar 31, 2011·Biochimica Et Biophysica Acta·Cristina Isabel Santos, Ana P Costa-Pereira
Oct 9, 2012·European Journal of Immunology·Elisabeth MaierJutta Horejs-Hoeck
Feb 15, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alfonso Quintás-Cardama, Srdan Verstovsek
Sep 6, 2015·Cancer Letters·Xun YuanKongming Wu
Dec 31, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S ChampiatA Marabelle
Apr 27, 2016·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yi-Ying WuTsu-Yi Chao
Jun 24, 2016·Journal of the National Cancer Institute·Michael D IglesiaBenjamin G Vincent
Oct 6, 2016·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J CapdevilaG Riesco Eizaguirre
Dec 9, 2016·Cell Death & Disease·Chiara Fazio, Luigi Ricciardiello
Dec 14, 2016·Annual Review of Pathology·Jon C AsterStephen C Blacklow
Mar 23, 2017·Nature Immunology·Alejandro V VillarinoJohn J O'Shea
Jun 28, 2017·Nature Reviews. Clinical Oncology·Mizuki NishinoF Stephen Hodi
Aug 10, 2017·Methods in Molecular Biology·Zhixiang Wang
Aug 19, 2017·Science·Mathias UhlenFredrik Ponten
Sep 16, 2017·Current Opinion in Oncology·Marzia Locatelli, Giuseppe Curigliano
Nov 2, 2017·Trends in Pharmacological Sciences·Ke ChenQi Liu
Feb 9, 2018·Cancer Science·Nahid ShahmarvandRobert S Ohgami
Aug 23, 2018·Nature Reviews. Endocrinology·Tracy S Wang, Julie Ann Sosa
Jan 15, 2019·Pathology, Research and Practice·Zonghui GuoJunjie Wang
Feb 6, 2019·Endocrinology and Metabolism Clinics of North America·Carolyn Dacey Seib, Julie Ann Sosa
Oct 13, 2019·Seminars in Cancer Biology·Yannick VerhoevenPeter A van Dam
Nov 16, 2019·BMC Cancer·Qiu-Yue ZhongGui-Hai Zhang

❮ Previous
Next ❯

Software Mentioned

GSEA
Genomic Commons
R Foundation for Statistical Computing
R

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis