State and parameter estimation of a neural mass model from electrophysiological signals during the status epilepticus

NeuroImage
Armando López-CuevasConsuelo Ventura-Mejía

Abstract

Status epilepticus is an emergency condition in patients with prolonged seizure or recurrent seizures without full recovery between them. The pathophysiological mechanisms of status epilepticus are not well established. With this argument, we use a computational modeling approach combined with in vivo electrophysiological data obtained from an experimental model of status epilepticus to infer about changes that may lead to a seizure. Special emphasis is done to analyze parameter changes during or after pilocarpine administration. A cubature Kalman filter is utilized to estimate parameters and states of the model in real time from the observed electrophysiological signals. It was observed that during basal activity (before pilocarpine administration) the parameters presented a standard deviation below 30% of the mean value, while during SE activity, the parameters presented variations larger than 200% of the mean value with respect to basal state. The ratio of excitation-inhibition, increased during SE activity by 80% with respect to the transition state, and reaches the lowest value during cessation. In addition, a progression between low and fast inhibitions before or during this condition was found. This method can be impleme...Continue Reading

References

Oct 20, 1990·BMJ : British Medical Journal·M D O'Brien
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Jan 1, 1972·Biophysical Journal·H R Wilson, J D Cowan
Oct 1, 1996·Epilepsia·E A CavalheiroM R Priel
May 25, 2002·The European Journal of Neuroscience·F WendlingP Chauvel
May 29, 2003·IEEE Transactions on Bio-medical Engineering·Fernando H Lopes da SilvaDemetrios N Velis
Sep 2, 2003·NeuroImage·K J FristonW Penny
Dec 4, 2003·NeuroImage·Olivier David, Karl J Friston
Sep 20, 2006·Epilepsia·Jerome Engel
Mar 17, 2007·Acta Neurologica Scandinavica·J W Y ChenC G Wasterlain
Aug 21, 2007·Lancet Neurology·Emilio PeruccaMeir Bialer
Oct 24, 2007·Journal of Neuroscience Methods·Alberto Morales-VillagránSilvia J López-Pérez
Feb 28, 2008·Nature Clinical Practice. Neurology·William C Stacey, Brian Litt
Apr 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Robert J Morgan, Ivan Soltesz
Jul 3, 2008·Nature Reviews. Neuroscience·William W Lytton
Jan 7, 2009·Annals of Biomedical Engineering·Niranjan ChakravarthyLeon Iasemidis
Feb 17, 2009·Emergency Medicine Clinics of North America·Dan MillikanRobert Silbergleit
Dec 31, 2009·Clinical Neuropathology·G MarucciM Giulioni
Mar 15, 2011·NeuroImage·Martin HavlicekVince D Calhoun
Mar 26, 2013·Computer Methods and Programs in Biomedicine·Armando López-CuevasKenia Pardo-Peña
Sep 10, 2013·International Journal of Molecular Sciences·Doodipala Samba Reddy, Ramkumar Kuruba
Mar 13, 2014·Epilepsy Research·Tobias LoddenkemperFrances E Jensen
Sep 10, 2014·Brain Research Bulletin·Chun-Lei HanFan-Gang Meng
Dec 9, 2014·Neuropsychiatric Disease and Treatment·Joanna H CoxAndrea E Cavanna

❮ Previous
Next ❯

Citations

Sep 9, 2018·The European Journal of Neuroscience·Xiaoya FanAntoine Nonclercq
Dec 29, 2017·The European Journal of Neuroscience·Xiaoya FanAntoine Nonclercq

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
E GiraldoG Castellanos-Dominguez
The American Journal of Nursing
M Kelly
© 2022 Meta ULC. All rights reserved