State and role of SRC family kinases in replication of herpes simplex virus 1

Journal of Virology
Yu Liang, Bernard Roizman

Abstract

An earlier report showed that infected cell protein no. 0 (ICP0) of herpes simplex virus 1 (HSV-1) interacts with the SH3 domains of a recently discovered adaptor protein, CIN85. Here, we report the following. (i) ICP0 also interacts with other SH3 domain-containing proteins and, in particular, with nonneuronal members of the Src kinase family. (ii) HSV-1 infection enhanced the activating phosphorylation of Tyr416 of the members of the Src kinase family, modestly enhanced the kinase activity of Src, and posttranslationally modified at least one additional member of the Src kinase family by phosphorylation in a manner dependent on the viral gene products ICP0, unique short 3 (U(S)3), and unique long 13 (U(L)13). (iii) To define the roles of Src kinase family members, we examined the accumulation of viral proteins, DNA, and mRNA and virus yields from wild-type mouse embryo fibroblasts and sibling cells lacking Src, Fyn, and Yes (SYF-); a mutant cell line, +Src, in which Src was restored to SYF- cells; and the mutant cell line (CSK-) lacking the negative regulator Csk gene of the Src kinase family. Representative alpha, beta, and gamma2 proteins accumulated in the largest amounts in SYF- cells and the smallest amounts in +Src comp...Continue Reading

References

May 1, 1987·Molecular and Cellular Biology·C A CartwrightW Eckhart
Jun 7, 1996·Biochimica Et Biophysica Acta·M T Brown, J A Cooper
Aug 1, 1996·Genes & Development·C A Lowell, P Soriano
Aug 1, 1997·Immunology Today·Y Collette, D Olive
Oct 29, 1997·Molecular and Cellular Biology·N P Klein, R J Schneider
Jan 22, 1998·Current Opinion in Structural Biology·F Sicheri, J Kuriyan
Jan 1, 1997·Annual Review of Cell and Developmental Biology·S M Thomas, J S Brugge
May 6, 1999·The EMBO Journal·R A KlinghofferP Soriano
Sep 16, 1999·The EMBO Journal·N P KleinR J Schneider
Dec 26, 2001·Oncogene·N Ichaso, S M Dilworth
Jun 28, 2003·The Journal of Biological Chemistry·Alexei V KurakinDale E Bredesen
Feb 14, 2004·Journal of Virology·Ryan Hagglund, Bernard Roizman
Jul 29, 2004·Journal of Virology·Gregory T MelroeDavid M Knipe
Oct 27, 2004·Biochemical and Biophysical Research Communications·Robert Roskoski
Apr 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yu LiangBernard Roizman
May 18, 2005·Proceedings of the National Academy of Sciences of the United States of America·Haidong GuBernard Roizman

❮ Previous
Next ❯

Citations

Nov 27, 2001·Clinical & Experimental Ophthalmology·S KlebeK A Williams
Jan 1, 2002·The Veterinary Quarterly·C van Maanen
Jan 19, 1999·Annual Review of Microbiology·H Kasamatsu, A Nakanishi
Feb 18, 2010·Future Virology·D Curanovic, Lw Enquist
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·J J H Chu, Priscilla L Yang
Jul 28, 2016·Scientific Reports·Rinki KumarGuruprasad R Medigeshi
Oct 24, 2007·The Journal of Biological Chemistry·Lubica SupekovaPeter G Schultz
Sep 11, 2009·Journal of Medicinal Chemistry·Andrew J StevensPaul A Keller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.