State of Play in Alzheimer's Disease Genetics

Journal of Alzheimer's Disease : JAD
Jin-Bao ZhuJin-Tai Yu

Abstract

Alzheimer's disease (AD), the main form of dementia in the elderly, is the most common progressive neurodegenerative disease characterized by rapidly progressive cognitive dysfunction and behavior impairment. AD exhibits a considerable heritability and great advances have been made in approaches to searching the genetic etiology of AD. In AD genetic studies, methods have developed from classic linkage-based and candidate-gene-based association studies to genome-wide association studies (GWAS) and next generation sequencing (NGS). The identification of new susceptibility genes has provided deeper insights to understand the mechanisms underlying AD. In addition to searching novel genes associated with AD in large samples, the NGS technologies can also be used to shed light on the 'black matter' discovery even in smaller samples. The shift in AD genetics between traditional studies and individual sequencing will allow biomaterials of each patient as the central unit of genetic studies. This review will cover genetic findings in AD and consequences of AD genetic findings. Firstly, we will discuss the discovery of mutations in APP, PSEN1, PSEN2, APOE, and ADAM10. Then we will summarize and evaluate the information obtained from GWAS...Continue Reading

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Citations

Nov 6, 2017·Journal of Alzheimer's Disease : JAD·Benedetta NacmiasSandro Sorbi
Jan 19, 2019·British Journal of Pharmacology·David S Reynolds
Aug 4, 2020·International Psychogeriatrics·Ellen E Lee
Sep 14, 2018·Clinical Epigenetics·Idoia Blanco-LuquinMaite Mendioroz
Jul 15, 2018·Acta Neuropathologica Communications·Mirta BorinSilvia Bolognin
Aug 23, 2017·Journal of Alzheimer's Disease : JAD·Tormod FladbyDag Aarsland
Jul 25, 2019·Cells·José Ángel Martínez-MenárguezEmma Martínez-Alonso
Jun 23, 2020·Journal of Alzheimer's Disease : JAD·Si-Yu WangTeng Jiang
Mar 7, 2021·Molecular Neurobiology·Lei ZhangYu Deng
Mar 16, 2021·Journal of Alzheimer's Disease : JAD·Irundika H K Dias, Helen R Griffiths
Jun 29, 2021·Dementia and Geriatric Cognitive Disorders Extra·Natalia SzejkoMichael Howard Bloch

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