State-of-the-art diagnosis and surgical treatment of acute peri-prosthetic joint infection following primary total hip arthroplasty

EFORT Open Reviews
Pablo A SlullitelFrancisco Piccaluga

Abstract

Acute peri-prosthetic joint infection (PJI) following total hip arthroplasty (THA) is a potentially devastating and undesired complication, with a prevalence of 0.3% to 2.9%. Its suspicion begins with a meticulous physical examination and anamnesis. Diagnosis should be made on the basis of the Musculoskeletal Infection Society criteria. Serum and synovial biomarkers are very useful tools when major criteria are absent.Although sometimes not possible due to medical conditions, surgery is usually the first line of treatment. Although its outcome is highly correlated with the isolated microorganism, irrigation and debridement with implant retention (DAIR) is the gold standard for treatment. Ideally, the prior approach should be proximally and distally extended to augment the field of view and remove all of the prosthetic modular components, that is, femoral head and acetabular insert.Given DAIR's unclear control of infection, with successful outcomes in the range of 30% to 95%, one- or two-stage revision protocols may play a role in certain cases of acute infections; nonetheless, further prospective, randomized studies are necessary to compare long-term outcomes between DAIR and revision surgeries.Following surgical treatment, len...Continue Reading

Associated Clinical Trials

References

Jul 1, 1982·Infection and Immunity·G D ChristensenE H Beachey
Aug 1, 1994·AJR. American Journal of Roentgenology·S TiggesJ R Roberson
Apr 1, 1996·The Journal of Bone and Joint Surgery. American Volume·D T TsukayamaR B Gustilo
Nov 25, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E F BerbariD R Osmon
Mar 30, 2001·The Journal of International Medical Research·O BilgenM S Bilgen
Jun 1, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Khaled SalehEdward McElfresh
Sep 11, 2003·Clinical Orthopaedics and Related Research·Andrej TrampuzRobin Patel
Mar 17, 2004·Acta Orthopaedica Scandinavica·Alejandro González Della ValleFrancisco Piccaluga
Oct 16, 2004·The New England Journal of Medicine·Werner ZimmerliPeter E Ochsner
Jan 20, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C E MarculescuD R Osmon
Jan 30, 2007·The Journal of Bone and Joint Surgery. British Volume·F BottnerC Götze
Jun 15, 2010·Clinical Orthopaedics and Related Research·José Cordero-Ampuero, Marisol de Dios
Jun 29, 2010·Clinical Orthopaedics and Related Research·J Christopher SherrellUNKNOWN Periprosthetic Infection Consortium
Jul 14, 2010·Clinical Orthopaedics and Related Research·Martin A ButtaroFrancisco Piccaluga
Oct 5, 2010·The Journal of Arthroplasty·Geoffrey H WestrichBarry D Brause
Mar 17, 2011·Expert Opinion on Pharmacotherapy·Jaime Esteban, José Cordero-Ampuero
May 10, 2011·Clinical Orthopaedics and Related Research·Loukas KoyonosJavad Parvizi
May 17, 2011·The Journal of Arthroplasty·Christina L JacovidesKwang Am Jung
Jul 28, 2011·The Journal of Bone and Joint Surgery. American Volume·Craig Della ValleUNKNOWN American Academy of Orthopaedic Surgeons
Sep 23, 2011·Clinical Orthopaedics and Related Research·Javad ParviziCharalampos G Zalavras
May 4, 2012·Clinical Orthopaedics and Related Research·Thomas K FehringTerence J Gioe
May 4, 2012·Clinical Orthopaedics and Related Research·Mohammad R RasouliJavad Parvizi
Jul 20, 2012·The Journal of Bone and Joint Surgery. American Volume·Javad ParviziAlan Seth Greenwald
Sep 8, 2012·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Carlo L RomanòDelia Romanò
Dec 12, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Douglas R OsmonUNKNOWN Infectious Diseases Society of America
Apr 24, 2013·Clinical Orthopaedics and Related Research·Mathias GlehrAndreas Leithner
May 22, 2013·Clinical Orthopaedics and Related Research·Pouya AlijanipourJavad Parvizi
Jun 19, 2013·Clinical Orthopaedics and Related Research·Erik HansenWilliam J Hozack
Sep 12, 2013·Interdisciplinary Perspectives on Infectious Diseases·Ana Lucia L LimaMarcelo B Rodrigues
Jan 15, 2014·Der Orthopäde·T WinklerC Perka
Feb 25, 2014·The Journal of Arthroplasty·Markus Lenski, Michael A Scherer
Mar 5, 2014·Clinical Orthopaedics and Related Research·Carl DeirmengianJavad Parvizi
Apr 29, 2014·The Journal of Arthroplasty·Javad ParviziUNKNOWN International Consensus Group on Periprosthetic Joint Infection
Jun 20, 2014·Clinical Orthopaedics and Related Research·Carl DeirmengianJavad Parvizi
Jul 16, 2014·Clinical Orthopaedics and Related Research·Guy MaozRichard Iorio
May 2, 2015·Journal of Pediatric Orthopedics·Andrew Chia Chen Chou, Arjandas Mahadev
May 28, 2015·Clinical Orthopaedics and Related Research·Martin A ButtaroFrancisco Piccaluga

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Methods Mentioned

BETA
total hip arthroplasty
ESR
lavage

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