State-of-the-art for CAR T-cell therapy for chronic lymphocytic leukemia in 2019

Journal for Immunotherapy of Cancer
Richard Lemal, Olivier Tournilhac

Abstract

Experience in the use of CAR T cells to treat CLL is limited, but safety and efficacy data are encouraging, suggesting that it may be possible to use CAR T cells in populations of CLL patients with particularly unfavorable prognoses. Mechanisms intrinsic to the pathophysiology of CLL undoubtedly explain the efficacy reported based on limited data for the first few series, and underlie the rationale of successive modulations in lymphodepletion schemes, transgene constructs, and, finally, the therapeutic association of CAR T cells with ibrutinib, which appears to be particularly promising. This review describes the published results and expected developments.

References

Aug 13, 2011·The New England Journal of Medicine·David L PorterCarl H June
Aug 27, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James N KochenderferSteven A Rosenberg
Oct 31, 2014·Cancer Immunology Research·Carolina BergerStanley R Riddell
Jun 9, 2016·The Journal of Clinical Investigation·Carlos A RamosGianpietro Dotti
Jan 13, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qingsong YinJan A Burger
Jul 18, 2017·The Journal of Clinical Investigation·Meixiao LongJohn C Byrd
Jul 18, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cameron J TurtleDavid G Maloney
Dec 2, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C BuskeUNKNOWN ESMO Lymphoma Consensus Conference Panel Members
Dec 10, 2017·Hematology·Kirsten Fischer, Michael Hallek
Dec 12, 2017·The New England Journal of Medicine·Sattva S NeelapuWilliam Y Go
Mar 24, 2018·Science·Carl H JuneMichael C Milone
May 13, 2018·Blood·John G Gribben
Jun 1, 2018·Nature·Joseph A FraiettaJ Joseph Melenhorst
Jun 19, 2018·Molecular Therapy : the Journal of the American Society of Gene Therapy·Mark B GeyerJae H Park

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Citations

Nov 27, 2019·Cancers·Bartosz PułaKrzysztof Jamroziak
Jul 17, 2020·Frontiers in Oncology·Lenka SedlarikovaEva Kriegova
Sep 6, 2019·International Journal of Molecular Sciences·Tom HoflandSanne H Tonino
Nov 6, 2020·Journal of Clinical and Experimental Hematopathology : JCEH·Yoshikane Kikushige
Dec 3, 2020·Vaccines·Robert PytlikPavel Klener
Nov 21, 2020·International Journal of Molecular Sciences·Wen-Ying LinYi-Yen Lee
Mar 30, 2021·Blood Reviews·Anna PetrackovaEva Kriegova
May 1, 2021·Blood Cancer Journal·Natalia Timofeeva, Varsha Gandhi
Jun 3, 2021·International Journal of Molecular Sciences·Veronika Mancikova, Michal Smida
Jun 10, 2021·Transplantation and Cellular Therapy·Sarah A HolsteinPhilip L McCarthy
Jul 3, 2021·Cancers·Elisavet VlachonikolaAnastasia Chatzidimitriou
Jul 3, 2021·International Journal of Molecular Sciences·Paolo SportolettiEmanuela Rosati
Jul 25, 2021·Cancers·Dimitra MavridouMichalis Aivaliotis

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Methods Mentioned

BETA
lymphodepletion
leukapheresis

Clinical Trials Mentioned

NCT03331198

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