State-of-the art pharmacotherapy for non-neovascular age-related macular degeneration

Expert Opinion on Pharmacotherapy
Daniele VerittiPaolo Lanzetta

Abstract

Introduction: Age-related macular degeneration (AMD) is the most common cause of blindness among the elderly in the industrialized world. While effective treatment is available for neovascular AMD, no therapy is successful for the non-neovascular form. Herein, the authors report the current knowledge on non-neovascular AMD pathogenesis and the promising research on treatments.Areas covered: In the present review, the authors summarize the most recent advances in the treatment of non-neovascular AMD and provide an update on current treatment strategies. Evidence available from preclinical and clinical studies and from a selective literature search is reported.Expert opinion: When investigating AMD, numerous pathological cascades and alterations of physiological processes have been investigated. It is well-known that AMD is a multifactorial disease, with environmental causes and genetics playing a role. Perturbations in multiple pathogenic pathways have been identified and this led to the development of several molecules directed at specific therapeutic targets.However, despite the huge research effort, the only proven approach so far is oral antioxidant supplementation. We believe that, in addition to successful advancement of p...Continue Reading

References

Feb 1, 1990·Ophthalmology·D PauleikhoffA C Bird
Sep 8, 1988·Biochimica Et Biophysica Acta·L E Rikans, D R Moore
Aug 1, 1987·Journal of the American College of Nutrition·M F Vandewoude, M G Vandewoude
May 1, 1980·Australian Journal of Ophthalmology·S H Sarks
Feb 17, 2000·The New England Journal of Medicine·S L FineA C Ho
Oct 18, 2000·Survey of Ophthalmology·S BeattyM Boulton
Jul 27, 2001·Ophthalmic Epidemiology·B E KleinS C Jensen
Aug 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Lincoln V JohnsonDon H Anderson
Sep 5, 2002·American Journal of Ophthalmology·Don H AndersonLincoln V Johnson
Apr 16, 2003·Archives of Ophthalmology·Redmer van LeeuwenPaulus T V M de Jong
Apr 28, 2004·Investigative Ophthalmology & Visual Science·Paul N BairdRobyn H Guymer
Nov 16, 2005·Archives of Ophthalmology·Matthew D DavisUNKNOWN Age-Related Eye Disease Study Group
Nov 16, 2005·Archives of Ophthalmology·Frederick L FerrisUNKNOWN Age-Related Eye Disease Study (AREDS) Research Group
Feb 7, 2006·Ophthalmology·Johanna M SeddonRon A Adelman
Jul 13, 2006·Archives of Ophthalmology·Brian ChuaPaul Mitchell
Jul 20, 2006·JAMA : the Journal of the American Medical Association·Dominiek D G DesprietPaulus T V M de Jong
Aug 8, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Phyllis H PengRichard M Rosenfeld
Oct 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jilin ZhouJanet R Sparrow
Feb 5, 2008·American Journal of Ophthalmology·Elaine W-T ChongRobyn H Guymer
Sep 10, 2008·Acta Ophthalmologica·Hemma ReschLeopold Schmetterer
Jun 25, 2010·Investigative Ophthalmology & Visual Science·Wai T WongFrederick L Ferris
Mar 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kang ZhangGeorge A Williams
Jan 27, 2012·The European Journal of Neuroscience·Trevor J McGillAlexandra Capela
Jan 28, 2012·Lancet·Steven D SchwartzRobert Lanza
Apr 25, 2012·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Daniele VerittiPaolo Lanzetta
May 2, 2012·Journal of Biomedicine & Biotechnology·Torsten FalkBrian S McKay
Feb 12, 2013·Ophthalmology·Eric H SouiedUNKNOWN Nutritional AMD Treatment 2 Study Group
Apr 16, 2013·Ophthalmology·Emily Y ChewUNKNOWN Age-Related Eye Disease Study Research Group

❮ Previous
Next ❯

Citations

Aug 18, 2020·AAPS PharmSciTech·Xinru ZhangShuai Gao
Dec 29, 2020·The British Journal of Ophthalmology·Liangbo L ShenLucian V Del Priore
Feb 20, 2021·Current Opinion in Ophthalmology·Justin C MusteRishi P Singh
Oct 29, 2021·Investigative Ophthalmology & Visual Science·Liangbo L ShenLucian V Del Priore

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Developments in Ophthalmology
Stephan Michels, Gerhard Garhöfer
Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
Mitsuyoshi AzumaThomas R Shearer
Klinische Monatsblätter für Augenheilkunde
Oliver ZeitzAntonia M Joussen
© 2021 Meta ULC. All rights reserved