State of the art review: oral and nasal vitamin B12 therapy in the elderly

QJM : Monthly Journal of the Association of Physicians
Emmanuel AndrèsT Vogel

Abstract

The objective of this narrative review was to provide an update on oral and nasal vitamin B12 (cobalamin) therapy in elderly patients. Relevant articles were identified by 'PubMed' and 'Scholar Google' search from January 2010 to July 2018 and through hand search of relevant reference articles. Additional studies were obtained from references of identified studies, the 'Cochrane Library' and the 'ISI Web of Knowledge'. Data retrieved from international meetings were also used, as was information retrieved from commercial sites on the web and data from 'CARE B12' research group. For oral vitamin B12 therapy, four prospective randomized controlled trials, eight prospective studies, one systematic and four reviews fulfilled our inclusion criteria. The studies included mainly or exclusively elderly patients (≥65-year-olds). In all of the studies, the mean age of the patients was at least 70 years except for two. The present review documents that oral vitamin B12 replacement at 1000 μg daily proved adequate to cure vitamin B12 deficiency, with a good safety profile. The efficacy was particularly marked when considering the noticeable improvement in serum vitamin B12 levels and haematological parameters, such as haemoglobin level, me...Continue Reading

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Citations

Apr 15, 2020·Nutrients·Jarosław KrzywańskiAndrzej Ziemba
Apr 10, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·O A ShavlovskayaYu D Yukhnovskaya

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