Static and dynamic alterations in the amplitude of low-frequency fluctuation in patients with amyotrophic lateral sclerosis

PeerJ
Xujing MaJiuquan Zhang

Abstract

Static changes in local brain activity in patients suffering from amyotrophic lateral sclerosis (ALS) have been studied. However, the dynamic characteristics of local brain activity are poorly understood. Whether dynamic alterations could differentiate patients with ALS from healthy controls (HCs) remains unclear. A total of 54 patients with ALS (mean age = 48.71 years, male/female = 36/18) and 54 (mean age = 48.30 years, male/female = 36/18) HCs underwent magnetic resonance imaging scans. To depict static alterations in cortical activity, amplitude of low-frequency fluctuations (ALFF) which measures the total power of regional activity was computed. Dynamic ALFF (d-ALFF) from all subjects was calculated using a sliding-window approach. Statistical differences in ALFF and d-ALFF between both groups were used as features to explore whether they could differentiate ALS from HC through support vector machine method. In contrast with HCs, patients with ALS displayed increased ALFF in the right inferior temporal gyrus and bilateral frontal gyrus and decreased ALFF in the left middle occipital gyrus and left precentral gyrus. Furthermore, patients with ALS demonstrated lower d-ALFF in widespread regions, including the right lingual g...Continue Reading

References

Oct 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B BiswalJ S Hyde
Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K J FristonR Turner
Sep 25, 1999·Neurology·C M EllisP N Leigh
May 15, 2003·Current Opinion in Neurobiology·Kalanit Grill-Spector
Jun 23, 2005·Journal of Cognitive Neuroscience·Deborah A HallA Quentin Summerfield
Jun 15, 2007·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Erin K ZimmermanAnna M Barrett
Dec 17, 2008·Lancet Neurology·Martin R TurnerKevin Talbot
Jun 26, 2010·Frontiers in Systems Neuroscience·Yan Chao-Gan, Zang Yu-Feng
Feb 1, 2011·Journal of the Neurological Sciences·Paolo VolantiVincenzo La Bella
Oct 4, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·Esther VerstraeteLeonard H van den Berg
Jan 10, 2012·Experimental Neurology·Mirco CosottiniGabriele Siciliano
Feb 7, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Wen-bin GuoJing-ping Zhao
Nov 14, 2012·Cerebral Cortex·Elena A AllenVince D Calhoun
Nov 20, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Wenbin GuoChangqing Xiao
Mar 7, 2013·Nature Reviews. Neuroscience·Wim Robberecht, Thomas Philips
Mar 8, 2014·Human Brain Mapping·Ruben SchmidtMartijn P van den Heuvel
Oct 14, 2014·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Qianqian WeiHuifang Shang
Mar 21, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Esther Verstraete, Bradley R Foerster
Jul 1, 2015·Journal of Neurology, Neurosurgery, and Psychiatry·Lu ChenDongsheng Fan
Jul 23, 2015·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Xujing MaHuafu Chen
Aug 19, 2015·Journal of Neurology, Neurosurgery, and Psychiatry·Emma BeeldmanRob J de Haan
Apr 15, 2016·Neuroinformatics·Chao-Gan YanYu-Feng Zang
May 4, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Xujing MaHuafu Chen
Jun 14, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·William HuynhMatthew C Kiernan
Dec 4, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·Jiuquan ZhangXiaoping Hu
Jan 10, 2017·Scientific Reports·Kristian LoeweMircea Ariel Schoenfeld
May 30, 2017·Lancet·Michael A van EsLeonard H van den Berg
Oct 6, 2017·Nature Reviews. Disease Primers·Orla HardimanLeonard H van den Berg
Aug 2, 2018·Frontiers in Aging Neuroscience·Weina LiXiaolin Zheng

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

VBM8
DPARSF
Data Processing Assistant for Resting fMRI ( DPARSF )
Temporal Dynamic Analysis ( TDA )
ALFF
xjview

Related Concepts

Related Feeds

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.