Static magnetic fields aggravate the effects of ionizing radiation on cell cycle progression in bone marrow stem cells

Micron : the International Research and Review Journal for Microscopy
Amir Sabet SarvestaniAzadeh Manoochehri Jahromi

Abstract

In order to evaluate the influence of static magnetic fields (SMF) on the progression of cell cycle as a monitor of presumptive genotoxicity of these fields, the effects of a 15 mT SMF on cell cycle progression in rat bone marrow stem cells (BMSC) were examined. The cells were divided into two groups. One group encountered SMF alone for 5h continuously but the other group exposed with X ray before treatment with SMF. The population of cells did not show any significant difference in the first group but the second group that was exposed with acute radiation before encountering SMF showed a significant increase in the number of cells in G(2)/M phase. So SMF has intensified the effects of X ray, where SMF alone, did not had any detectable influence on cell cycle. These findings suggest that magnetic fields (MF) play their role by increasing the effects of genotoxic agents and because of the greater concentration of free radicals in the presence of radical pair producers, this effect is better detectable.

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Citations

Feb 9, 2013·In Vitro Cellular & Developmental Biology. Animal·Fatemeh Javani JouniMansoureh Movahedin
Apr 27, 2012·World Journal of Surgical Oncology·Khaled AljarrahFawzi M Alsheyab
Dec 19, 2013·Journal of Radiation Research·Laura TeodoriDario Coletti
Dec 8, 2015·Neuroscience Letters·Manouchehr SafariHadi Hasanzadeh
Mar 16, 2016·Progress in Biophysics and Molecular Biology·Wendell Wagner Campos AlbuquerqueAna Lúcia Figueiredo Porto
Sep 13, 2013·BioMed Research International·Soumaya GhodbaneHafedh Abdelmelek
Jul 20, 2014·Differentiation; Research in Biological Diversity·Fatemeh Javani JouniMansoureh Movahedin
Oct 26, 2018·The British Journal of Radiology·Jonathan Kim MohajerGiuseppe Schettino
Mar 20, 2017·Cellular and Molecular Bioengineering·Maryam SadriFazel Sahraneshin Samani
Sep 9, 2020·Ecotoxicology and Environmental Safety·Tatjana TasićSilvio R De Luka

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