Static pressure-volume curve characteristics are moderate estimators of optimal airway pressures in a mathematical model of (primary/pulmonary) acute respiratory distress syndrome

Intensive Care Medicine
Dick G MarkhorstAdrianus J van Vught

Abstract

To study the value of objective pressure-volume characteristics for predicting optimal airway pressures and the development of atelectasis and overstretching during a structured lung volume recruitment procedure with subsequent reduction in airway pressures. We used a mathematical model of a lung with adjustable characteristics of acute respiratory distress syndrome (ARDS) characteristics. Simulations were performed in five grades of ARDS in the presence of pure alveolar or combined alveolar-small airway closure as well complete or incomplete lung volume recruitability. For each simulation optimal end-expiratory pressure was determined. A static pressure-volume curve was constructed and objective characteristics of this curve calculated. The predictive value of these characteristics for end-expiratory atelectasis, overstretching, and optimal end-expiratory pressure was assessed. Simultaneous alveolar recruitment and overstretching during inflation were more pronounced than alveolar derecruitment and overstretching during deflation. End-expiratory pressure needed to prevent significant alveolar collapse in severe ARDS resulted in maximal safe tidal volumes that may be insufficient for adequate ventilation using conventional mech...Continue Reading

References

Jan 1, 1992·Intensive Care Medicine·B Lachmann
Nov 1, 1967·Japanese Heart Journal·N C StaubM L Pearce
Feb 1, 1967·Journal of Applied Physiology·N C StaubM L Pearce
Jun 1, 1995·American Journal of Respiratory and Critical Care Medicine·L GattinoniF Valenza
Jan 1, 1994·American Journal of Respiratory and Critical Care Medicine·P PelosiL Gattinoni
Apr 28, 1993·JAMA : the Journal of the American Medical Association·L GattinoniR Fumagalli
Nov 14, 1997·American Journal of Respiratory and Critical Care Medicine·V M RanieriA S Slutsky
Feb 6, 1998·Journal of Applied Physiology·J G VenegasB A Simon
Jul 9, 1998·American Journal of Respiratory and Critical Care Medicine·K G Hickling
Feb 15, 2000·American Journal of Respiratory and Critical Care Medicine·R S HarrisJ G Venegas
Jul 4, 2001·American Journal of Respiratory and Critical Care Medicine·S CrottiL Gattinoni
Sep 3, 2002·Current Opinion in Critical Care·Keith G Hickling
Sep 28, 2002·Journal of Medical Engineering & Technology·F D'OsualdoM Isola
Jan 1, 1964·Journal of Applied Physiology·E SALAZAR, J H KNOWLES

❮ Previous
Next ❯

Citations

Dec 1, 2011·Critical Care : the Official Journal of the Critical Care Forum·Martin C J Kneyber
Mar 18, 2008·Critical Care : the Official Journal of the Critical Care Forum·Dick MarkhorstMarc van Heerde
Aug 11, 2005·Intensive Care Medicine·Guillermo M AlbaicetaFrancisco Taboada
Jun 2, 2005·Current Opinion in Critical Care·Luciano GattinoniPietro Caironi
Oct 20, 2012·Critical Care Medicine·Martin C J KneyberDick G Markhorst
Jul 27, 2010·Computer Methods and Programs in Biomedicine·K L SteimleS Andreassen
Nov 13, 2009·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Mouloud A DenaïGary H Mills
Sep 8, 2012·IEEE Transactions on Bio-medical Engineering·Christoph SchranzKnut Möller
Jun 15, 2018·PloS One·Laura Ellwein FixHenry J Rozycki
Jun 15, 2007·Advances in Physiology Education·Wolfgang M KueblerAxel R Pries

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.