Static, transient and permanent organization of GABA receptor expression in calbindin-positive interneurons in response to amygdala kindled seizures

Journal of Neurochemistry
R MeguroM O Poulter

Abstract

We tested the hypothesis that experimentally produced epilepsy (by kindling) may induce changes in GABAA receptor expression in some but not all interneuron populations. Using laser capture microdissection and quantitative polymerase chain reaction (QPCR) analysis, GABAA receptor alpha subunit expression in calbindin- (CBir) and parvalbumin- (Parvir) immunoreactive interneurons was compared between normal brains and brains in which amygdala kindled seizure responses were permanently established. Two weeks after the last seizure response, Cbir neurons in the hilus and/or perirhinal cortex up-regulated the expression of alpha2, alpha3 and alpha5 subunit mRNAs up to 900%. In contrast, no changes were found in Parvir neurons. In Cbir neurons contralateral to the amygdala kindling site alpha1 subunit mRNA expression was increased. In both Cbir and Parvir neurons, the coordinated subunit expression patterns ipsilateral (fully kindled) and contralateral (partially kindled) to the kindling site suggested that permanent and transient co-expressional relationships occur respectively. In the perirhinal cortex alpha2 protein was up-regulated in the processes but not in the cell somas of calbindin-positive neurons, whereas alpha3 subunit pr...Continue Reading

References

Aug 1, 1979·Experimental Eye Research·A Pellegrino de Iraldi, J P Corazza
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Jun 1, 1972·Physiology & Behavior·D C McIntyre, A Molino
Jun 6, 1994·Neuroscience Letters·W KamphuisF H Lopes da Silva
Jan 1, 1996·Hippocampus·T F Freund, G Buzsáki
Jul 9, 1999·Neurochemistry International·J M FritschyF Loup
Dec 29, 2000·International Review of Neurobiology·D C McIntyre, M O Poulter
Jan 17, 2002·The Journal of Comparative Neurology·Ina BrünigJean-Marc Fritschy
Apr 18, 2002·Brain Pathology·Douglas A CoulterWolfgang Löscher
Aug 2, 2002·Epilepsy Research·Dan C McIntyreKrista Gilby
Jan 29, 2003·Current Opinion in Pharmacology·Dorothy M Jones-Davis, Robert L Macdonald
Nov 20, 2003·Trends in Neurosciences·Miles A Whittington, Roger D Traub
Feb 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zul MeraliHymie Anisman
May 7, 2004·The European Journal of Neuroscience·B HutcheonM O Poulter

❮ Previous
Next ❯

Citations

Jan 7, 2014·Trends in Neurosciences·Jonathan D PollockJohn S Satterlee
Sep 22, 2006·The European Journal of Neuroscience·Cezar GavriloviciMichael O Poulter
Jun 11, 2005·Epilepsia·Dieter Schmidt, Wolfgang Löscher
Oct 22, 2019·Journal of Neuropathology and Experimental Neurology·Harald StefanitsThomas Czech
Aug 21, 2010·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Joseph P SteinerMichael O Poulter

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.