Static versus dynamic intensity-modulated radiotherapy: Profile of integral dose in carcinoma of the nasopharynx.

Journal of Medical Physics
K S JothybasuP K Julka

Abstract

This study is aimed to evaluate the impact of static and dynamic intensity modulated radiotherapy (IMRT) delivery techniques planned with Eclipse TPS on the integral dose to the healthy normal tissue surrounding the tumor-bearing area and to the volume receiving doses < 5 Gy in patients with carcinoma nasopharynx treated with Simultaneous Integrated Boost IMRT (SIB-IMRT). Ten patients with carcinoma nasopharynx were chosen for this dosimetric study. IMRT plans were generated with 6X using dynamic multileaf collimator (DMLC) and static multileaf collimator (SMLC) with 5, 10 and 15 intensity levels (L). Integral dose, volume receiving 5 Gy, number of monitor units (MU) is compared against DMLC. The mean difference in the MU delivered per fraction between 5, 10 and 15 L SMLC and DMLC was -13.25% (P < 0.001, with paired t test), -11.82% (P < 0.001) and -10.81% (P < 0.001), respectively. The mean difference in the integral dose with 5, 10 and 15 L compared to DMLC was -2.96% (P < 0.001), -2.67% (P = 0.016) and -0.39% (P = 0.430), respectively. However, the difference in low-dose volume (V5Gy) was statistically insignificant with mean difference of 0.60% (P = 0.23), 1.18% (P = 0.017) and 1.70% (P = 0.078), respectively for 5, 10 and ...Continue Reading

References

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Citations

Oct 7, 2014·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Xiaofang DaiC-M Ma
Aug 12, 2017·Physics in Medicine and Biology·Bilal A TahirRob H Ireland
Jan 18, 2021·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Yin ZhangNrusingh C Biswal

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Software Mentioned

Eclipse TPS
Eclipse Dose Volume Optimizer
Eclipse

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