Statin and fibrate associated myopathy: study of eight patients

Arquivos de neuro-psiquiatria
Alzira A Siqueira CarvalhoRaul Alberto Valiente

Abstract

Lipid-lowering drugs have been occasionally associated with neuromuscular symptoms and muscle biopsy changes. We reported the clinical course and the muscle biopsy in eight patients with hyperlipoproteinemia, treated with lipid -lowering drugs (statins/fibrates). Five patients had myalgias while; in two cases there was proximal muscle weakness. All patients became asymptomatic after the withdrawal of the drug, although creatine kinase remained elevated. We performed muscle biopsy in six cases from three months to two years after suspension of the drug. We found variation in fibers diameters in all cases, with necrosis of fibers in five cases, inflammatory infiltration in one case, the presence of vacuolated fiber in one patient and ragged-red fibers in three subjects. We concluded that although the muscle biopsy findings were not specific, the prolonged use of statins and or fibrates might induce a chronic myopathy even in the absence of symptoms.

References

Aug 27, 1992·The New England Journal of Medicine·B B SchalkeH P Hartung
Jan 1, 1985·Acta Neuropathologica·A BardosiH H Goebel
Aug 1, 1995·Australian and New Zealand Journal of Medicine·J D EnglandG M Halmagyi
May 31, 1997·Lancet·N GiordanoC Gennari
Jul 6, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·M UcarR Dahlqvist
Jan 5, 2002·The Medical Journal of Australia·I Hamilton-Craig
Jul 20, 2002·Journal of Cardiovascular Pharmacology·Helmut SinzingerBernhard A Peskar
Aug 2, 2002·Current Opinion in Lipidology·Marc Evans, Alan Rees
Oct 2, 2002·Annals of Internal Medicine·Paul S PhillipsUNKNOWN Scripps Mercy Clinical Research Center
Apr 4, 2003·JAMA : the Journal of the American Medical Association·Paul D ThompsonRichard H Karas

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Citations

Feb 18, 2014·Translational Research : the Journal of Laboratory and Clinical Medicine·Dhiaa A TahaPavel Gershkovich
May 25, 2005·Clinics in Geriatric Medicine·G Andres Quiceno, John J Cush
Apr 18, 2007·The American Journal of Cardiology·David Demitry BoltanWilliam Clifford Roberts
Mar 26, 2008·Toxicologic Pathology·F Russell WestwoodKevin Randall
Aug 2, 2006·Muscle & Nerve·Jill M SladeRonald A Meyer
Aug 12, 2009·Muscle & Nerve·Agnes Supala-BergerEufrosina Young-McLain
Apr 16, 2020·TheScientificWorldJournal·Bharti ChogtuSneha G Kalthur

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Annals of Internal Medicine
Paul S PhillipsScripps Mercy Clinical Research Center
JAMA : the Journal of the American Medical Association
Paul D ThompsonRichard H Karas
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