Statin Antiarrhythmic Effect on Atrial Fibrillation in Statin-Naive Patients Undergoing Cardiac Surgery: A Meta-Analysis of Randomized Controlled Trials

Journal of Cardiovascular Pharmacology and Therapeutics
Yousef RezaeiNasim Arjmand

Abstract

Statin therapy has been thought to improve outcomes in cardiac surgeries. We aimed to determine the statin effects on the development of postoperative atrial fibrillation (AF), hospital length of stay (LOS), and inflammatory status in patients undergoing cardiac surgeries. A systematic literature search in databases was performed, until January 2015. Randomized clinical trial (RCT) studies evaluating statin effect on statin-naive patients with sinus rhythm undergoing cardiac surgeries were eligible to be analyzed. Twelve RCTs involving 1116 patients, 559 receiving statin and 557 receiving control regimen, were analyzed. Postoperative AF occurred in 17.9% and 36.1% of patients in the statin and control groups, respectively. The statin therapy was associated with decreases in the postoperative AF (risk ratio [RR] 0.50, 95% confidence interval [CI] 0.41-0.61, P < .000010), hospital LOS (mean difference in days, RR -0.44, 95% CI -0.67 to -0.20, P = .0002), and postoperative C-reactive protein (CRP) compared with control (mean difference in mg/L, RR -12.37, 95% CI -23.87 to -0.87, P = .04). The beneficial effects on AF and CRP were more marked in patients receiving atorvastatin compared to other statins. Decrease in postoperative AF...Continue Reading

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Citations

Dec 7, 2016·Critical Care : the Official Journal of the Critical Care Forum·Alessandro PutzuGiovanni Landoni
Dec 3, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Iveta GasparovaPeter Kruzliak
Jul 6, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Oliver Juul OlesenEmil Loldrup Fosbøl
Sep 11, 2019·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Yousef RezaeiSaeid Hosseini
Nov 9, 2019·Current Anesthesiology Reports·Peter S BurrageBen O'Brien
Mar 4, 2021·Journal of Cardiovascular Development and Disease·Homa NomaniAmirhossein Sahebkar
Mar 16, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Yi-Jen HuangKwua-Yun Wang
Aug 28, 2021·Cancers·Gennaro Carmine SemeraroDaniela Maria Cardinale

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coronary artery bypass

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