Abstract
Robust evidence is lacking on optimal timing of statin administration and its impact on patient outcomes. This study aims to evaluate among incident statin users the relationship between those prescribed evening vs. daily dosing instructions, medication adherence, and changes in low-density lipoprotein cholesterol (LDL-c). This is an observational cohort study at Sutter Health, a community-based healthcare system, 2010-2016. Patients were ≥ 35 years of age as of the first statin prescription (baseline), with 12 to 36 months of electronic health record activity before and after baseline. Incident use was defined as no statin prescription in 12 months prior to baseline. Differences in medication adherence (proportion of days covered ≥ 0.80) over 12 months from baseline and mean change in LDL-c between 12 and 24 months from baseline were measured using regression modeling, adjusting for baseline demographics and clinical, prescriber, and statin characteristics. Among 31,252 patients with valid statin prescriptions between 2010 and 2016, 5099 eligible incident statin users (mean age, 63 years) were identified, of whom 53% were prescribed evening and 47% daily dosing instructions. No difference in likelihood of statin adherence over...Continue Reading
References
Jul 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·Y SaitoY Goto
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·T S ParkerE H Ahrens
Jan 1, 1993·European Journal of Clinical Pharmacology·W KruseG Schlierf
Jul 1, 1996·Journal of Clinical Pharmacology·D D CillaA J Sedman
Jan 1, 1997·Journal of Clinical Epidemiology·J F Steiner, A V Prochazka
Nov 26, 2002·British Journal of Clinical Pharmacology·Paul D MartinDennis W Schneck
Oct 4, 2003·BMJ : British Medical Journal·Alan WallaceGreg Rubin
Oct 15, 2005·Medical Care·Hude QuanWilliam A Ghali
Nov 24, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Roda PlakogiannisDavid Taft
Jan 4, 2007·The Annals of Pharmacotherapy·Roda Plakogiannis, Henry Cohen
Dec 4, 2009·Journal of Managed Care Pharmacy : JMCP·Jason YeawDaniel B Smith
Apr 3, 2013·Annals of Internal Medicine·Huabing ZhangAlexander Turchin
Apr 3, 2013·Annals of Internal Medicine·Scott M Grundy
Sep 4, 2013·Clinical Therapeutics·Sang-Hyun KimSeong Hoon Park
Nov 14, 2013·Circulation·Neil J StoneUNKNOWN American College of Cardiology/American Heart Association Task Force on Practice Guidelines
Jan 1, 2012·Journal of Personalized Medicine·Philipp WalterKurt E Hersberger
Apr 24, 2015·Pharmacoepidemiology and Drug Safety·Jessica M FranklinNiteesh K Choudhry
Sep 7, 2016·Lancet·Salim Yusuf
Nov 14, 2016·JAMA : the Journal of the American Medical Association·UNKNOWN US Preventive Services Task ForceMichael P Pignone
Nov 15, 2016·JAMA Cardiology·Joseph A SalamiKhurram Nasir
Jun 10, 2017·Atherosclerosis·Valeria GuglielmiFrancesco Lapi
Jul 13, 2017·Trials·Karolina ObońskaJacek Kubica
Aug 23, 2017·Journal of Clinical Lipidology·Kamal AwadUNKNOWN Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group
Dec 6, 2017·Journal of General Internal Medicine·Michael J StirrattC Ann Gakumo
Dec 11, 2017·American Heart Journal·Alan S GoJoan C Lo
Jan 19, 2018·Journal of Managed Care & Specialty Pharmacy·Yuze YangJames Green
Jan 24, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Richard Ofori-AsensoSophia Zoungas