Statin drugs do not affect serum complement activation in vitro

Scandinavian Journal of Immunology
K T LappegårdTom Eirik Mollnes

Abstract

Statin drugs prevent coronary heart disease through anti-inflammatory mechanisms in addition to the well-known reduction of low-density lipoproteins. The complement system plays an essential role in the inflammatory response and has been postulated to be modified by statins. A direct role for statins in complement activation, however, has not been previously investigated. We therefore studied the effect of statins on in vitro complement activation. Pravastatin, atorvastatin and the active metabolite of the latter, ortho-hydroxy atorvastatin, were added to normal human serum and incubated for 1 h in the absence or presence of aggregated immunoglobulin (classical pathway activation) or cobra venom factor (alternative pathway activation). The degree of complement activation, as detected by specific complement-activation products for the classical pathway (C1rs-C1-inhibitor complexes), the combined classical and lectin pathway (C4bc), the alternative pathway (C3bBbP) and the final common pathway (C3bc and TCC), was not affected by pre-incubation of the serum with any of the statins. Statins do not affect complement activation directly, but indirect effects in vivo may well be operative.

References

Apr 1, 1995·The American Journal of Medicine·A MuscariP Puddu
Feb 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·A NotarbartoloC Patrono
Jun 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·K H Le Quan SangM A Devynck
Feb 23, 1995·The New England Journal of Medicine·T J AndersonP Ganz
Oct 1, 1994·The American Journal of Cardiology·J L IsaacsohnH R Black
Jan 1, 1997·The American Journal of Cardiology·M BevilacquaG Norbiato
Aug 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·A D MaraisJ Mountney
Nov 10, 1998·Journal of the American Society of Nephrology : JASN·A YoshimuraT Ideura
Mar 4, 2000·Molecular Immunology·F Niculescu, H Rus
Apr 4, 2002·Trends in Immunology·Tom E MollnesJohn D Lambris
Oct 16, 2002·Circulation·David J Lefer
Dec 18, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Thomas A Clarke, Lucy A Waskell
Jun 10, 2003·Clinical Science·Justin C Mason
Jun 24, 2003·The American Journal of Pathology·Remco NijmeijerC Erik Hack
Aug 20, 2003·Circulation·Jacqueline SawUNKNOWN Clopidogrel for the Reduction of Events During Observation Investigators

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibodies: Complement Activation

The complement system can be activated by antigen-associated antibody. In the classical pathway of complement activation, C1q, C4b, and C3b are all able to bind to the Fc portion of IgG or IgM. Find the latest research on antibodies and complement activation here.

Alternative Complement Pathway

The Alternative Complement Pathway is part of the innate immune system, and activation generates membrane attack complexes that kill pathogenic cells. Discover the latest research on the Alternative Complement Pathway.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.