Statin exposure during first trimester of pregnancy is associated with fetal ventricular septal defect

International Journal of Cardiology
Ming-Sum LeeLewei Duan

Abstract

A growing number of young women are exposed to statins during their first trimester of pregnancy. The goal of this study is to examine if first trimester statin exposure is associated with an increase in risk of fetal congenital cardiac anomalies. In a cohort of 379,238 pregnancies, we examined the risk of fetal congenital cardiac anomalies in association with maternal exposure to statin therapy during the first trimester of pregnancy using logistic regression models and propensity score matching methods. 280 women were exposed to statins. Congenital cardiac anomalies were present in 14 (5.0%) of pregnancies exposed to statin and 5282 (1.4%) of non-exposed pregnancies. First-trimester statin exposure was associated with an increased risk of ventricular septal defect (adjusted odds ratio [OR] 3.3, 95% confidence interval [CI]l 1.8-6.0, p < 0.001). This association was confirmed in an analysis using a propensity score-matched cohort (OR 4.7, 95% CI 2.0-10.8, p < 0.001). Exposure to statins during the first trimester of pregnancy is associated with fetal ventricular septal defect.

Citations

Jan 18, 2019·Circulation Research·Natalie C WardRobert H Eckel
Dec 12, 2019·British Journal of Clinical Pharmacology·Maria EllfolkHeli Malm
Nov 18, 2020·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Victoria L RudlandLeonie Callaway
May 28, 2021·Atherosclerosis·Amir Vahedian-AzimiAmirhossein Sahebkar

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