Statin induced necrotizing autoimmune myopathy

Journal of the Neurological Sciences
Suma Babu, Yuebing Li

Abstract

Statin induced necrotizing autoimmune myopathy (SINAM) is a recently characterized entity belonging to the spectrum of statin myotoxicity. It is a more severe form, and is usually associated with significant proximal muscle weakness, strikingly elevated creatine kinase levels and persistent symptoms despite statin discontinuation. The characteristic pathological finding is a marked muscle fiber necrosis with minimal or no inflammation on muscle biopsy. SINAM is an autoimmune disorder associated with an antibody against 3-hydroxy-3-methyglutaryl-coenzyme A reductase (HMGCR), and the antibody titer is a useful marker for assessing treatment response. However, anti-HMGCR positive myopathies are also caused by unknown etiologies other than statin exposure, especially in the younger population. SINAM should be promptly recognized as immunosuppressive therapy can improve its clinical outcome significantly. Further research is needed to elucidate its pathogenesis and provide evidence based guidelines for management.

References

Feb 13, 1975·The New England Journal of Medicine·A Bohan, J B Peter
Feb 1, 1989·British Journal of Rheumatology·P BrownM D Evans
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Jun 5, 2001·The American Journal of Medicine·B NoëlR G Panizzon
Jul 27, 2002·Journal of the American College of Cardiology·Richard C PasternakUNKNOWN National Heart, Lung and Blood Institute
Aug 21, 2002·Circulation·Richard C PasternakUNKNOWN National Heart, Lung and Blood Institute
Aug 13, 2003·Neurology·M F G van der MeulenM de Visser
Jul 16, 2005·Journal of Atherosclerosis and Thrombosis·Shigeru MorikawaTatsuhiko Kodama
Dec 14, 2005·Archives of Internal Medicine·Karen E HansenJames H Stein
Feb 3, 2006·Cardiovascular Drugs and Therapy·Eric BruckertBernard Bégaud
May 4, 2006·Muscle & Nerve·Georgirene D VladutiuPaul S Phillips
Jan 24, 2007·Neuromuscular Disorders : NMD·Merrilee NeedhamFrank L Mastaglia
May 3, 2007·Clinical Therapeutics·Matthew SilvaPritesh Gandhi
Jun 16, 2007·British Medical Bulletin·Paola BrancaccioFrancesco Mario Limongelli
Sep 26, 2007·American Heart Journal·Lizzy M BrewsterGert A van Montfrans
Mar 28, 2008·Current Neurology and Neuroscience Reports·Kristofer A Radcliffe, William W Campbell
Jul 1, 2008·Atherosclerosis·Christos VaklavasGeorge D Giannoglou
Jul 25, 2008·The New England Journal of Medicine·UNKNOWN SEARCH Collaborative GroupR Collins
Oct 24, 2008·Current Opinion in Rheumatology·Georgirene D Vladutiu
Oct 9, 2009·Muscle & Nerve·Phyllis Grable-EspositoAnthony A Amato
Dec 28, 2010·Atherosclerosis·Ankur Gupta, Paul D Thompson
Dec 14, 2011·Atherosclerosis·Santosh Padala, Paul D Thompson
Sep 8, 2012·Current Opinion in Rheumatology·Livia Casciola-Rosen, Andrew L Mammen
Mar 23, 2013·Muscle & Nerve·Payam Mohassel, Andrew L Mammen
Jun 5, 2014·Clinical Pharmacology and Therapeutics·A AlfirevicM Pirmohamed
Jul 6, 2014·Current Rheumatology Reports·Jemima Albayda, Andrew L Mammen

❮ Previous
Next ❯

Citations

Oct 31, 2015·Expert Review of Clinical Immunology·Priyadarshini LoganathanRohit Aggarwal
Nov 21, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Merrilee Needham, Frank L Mastaglia
May 6, 2016·Neurology India·Samir PatelPooja Gupta
May 18, 2016·BMC Ear, Nose, and Throat Disorders·Linh Q NgoElie Gertner
Jan 25, 2017·Rheumatology·Tasneam ShagroniOnome Whiteru
Feb 17, 2017·Current Opinion in Lipidology·Lisa Christopher-Stine, Pari Basharat
Dec 7, 2017·Pharmacogenomics·Maria Alice V WillrichLinnea M Baudhuin
Jan 6, 2017·Praxis·Andreas OestmannFernand Repond
Jan 5, 2019·Clinical Pediatrics·Kallol K SetRajkumar Agarwal
Apr 3, 2020·Expert Opinion on Drug Safety·Dragana NikolicManfredi Rizzo
Jul 19, 2016·Current Opinion in Neurology·Robin S Howard
May 17, 2019·BMJ Case Reports·Haisam AbidEdward Bischof
Jun 4, 2016·Current Opinion in Cardiology·Negar Maghsoodi, Anthony S Wierzbicki
May 24, 2020·BMJ Case Reports·Cansu Güngör, Udo Carl Wieshmann
Aug 2, 2017·Journal of Clinical Medicine·Radha Ramachandran, Anthony S Wierzbicki
May 10, 2019·BMJ Case Reports·Mitchell Pitlick, Floranne Ernste
Mar 30, 2021·Der Radiologe·Matthias Bollow

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

© 2021 Meta ULC. All rights reserved