Statin prescription in men and women at cardiovascular risk: to whom and when?

Current Opinion in Cardiology
Jasper J Brugts, Jaap W Deckers

Abstract

To review the recent evidence of the effectiveness of statin therapy in the primary prevention of cardiovascular disease in men and women without established cardiovascular disease (CVD). The use of statins in patients without established CVD has important public health implications. Until recently, research has provided ambiguous answers and the reliability of treatment in older people (>65 years), women, and patients with diabetes has remained uncertain, mainly because of a lack of data or inconsistent findings within these clinically defined groups. The Justification for the use of Statins in Primary Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) demonstrated a significant benefit of rosuvastatin in low-risk patients with no apparent vascular disease, low-density lipoprotein levels of less than 3.4 mmol/l, and elevated high sensitivity C-reactive protein. The latest meta-analysis of statins in 70 000 patients without established CVD confirmed the overall benefit of statins in these low-risk patients and found no significant heterogeneity of the treatment effect in the clinically defined subgroups of elderly (>65 years), women, and patients with diabetes. The use of statins in low-risk patients without CV...Continue Reading

References

Oct 15, 1994·Lancet·J E PedersenA Banning
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Nov 30, 2002·Lancet·James ShepherdUNKNOWN PROSPER study group. PROspective Study of Pravastatin in the Elderly at Risk
Dec 20, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatm
Nov 11, 2008·The New England Journal of Medicine·Paul M RidkerUNKNOWN JUPITER Study Group
Feb 18, 2009·Annals of Internal Medicine·Mark J PletcherLee Goldman
Mar 4, 2010·JAMA : the Journal of the American Medical Association·F Gerald R FowkesUNKNOWN Aspirin for Asymptomatic Atherosclerosis Trialists

❮ Previous
Next ❯

Citations

Apr 17, 2013·European Journal of Clinical Pharmacology·Helle Wallach-KildemoesTheis Lange
Nov 11, 2010·Current Cardiology Reports·Ilan GottliebCarlos Eduardo Rochitte
Oct 9, 2015·Journal of Evaluation in Clinical Practice·Helle Wallach-KildemoesHálfdán Pétursson
Mar 6, 2012·The American Journal of Medicine·C Michael MinderRoger S Blumenthal
Apr 5, 2018·Cardiorenal Medicine·Haroon KamranSamy I McFarlane
Jun 6, 2013·Nature Reviews. Cardiology·Željko Reiner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.