Statin pretreatment and risk of in-hospital atrial fibrillation among patients undergoing cardiac surgery: a collaborative meta-analysis of 11 randomized controlled trials

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Giuseppe PattiKausik K Ray

Abstract

Statin pretreatment in patients undergoing cardiac surgery is understood to prevent postoperative atrial fibrillation (AF). However, this is based on observational and limited randomized trial evidence, resulting in uncertainty about any genuine anti-arrhythmic benefits of these agents in this setting. We therefore aimed to quantify precisely the association between statin pretreatment and postoperative AF among patients undergoing cardiac surgery. A detailed search of MEDLINE and PubMed databases (1st January 1996 to 31st July 2012) was conducted, followed by a review of the reference lists of published studies and correspondence with trial investigators to obtain individual-participant data for meta-analysis. Evidence was combined across prospective, randomized clinical trials that compared the risk of postoperative AF among individuals randomized to statin pretreatment or placebo/control medication before elective cardiac surgery. Postoperative AF was defined as episodes of AF lasting ≥5 min. Overall, 1105 participants from 11 trials were included; of them, 552 received statin therapy preoperatively. Postoperative AF occurred in 19% of these participants when compared with 36% of those not treated with statins (odds ratio 0....Continue Reading

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Citations

Jan 20, 2017·Current Atherosclerosis Reports·Rose Mary Ferreira Lisboa da Silva
Jan 14, 2020·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jahangir A KhanKati M Järvelä
Dec 7, 2018·Journal of Cardiovascular Pharmacology·Georgios GiannopoulosSpyridon Deftereos
Mar 4, 2021·Journal of Cardiovascular Development and Disease·Homa NomaniAmirhossein Sahebkar
Apr 11, 2021·BMC Cardiovascular Disorders·Sevket T TurkkoluCengiz Köksal
Jul 5, 2021·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Alireza OraiiFarzad Masoudkabir
Jul 19, 2021·Revista Portuguesa De Cardiologia·Alireza OraiiFarzad Masoudkabir
Aug 14, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Seyedeh Hamideh MortazaviSaeed Sadeghian

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