Statin Therapy and the Incidence of Thromboembolism and Vascular Events Following Liver Transplantation.

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Peter E FrascoAmit K Mathur

Abstract

Statin therapy may reduce the risk of venous thromboembolism (VTE), which may impact solid organ transplant outcomes. We evaluated the incidence of VTE and other complications after liver transplantation stratified by hyperlipidemia status and statin use using a retrospective cohort study approach. We reviewed all primary orthotopic liver transplantation (OLT) records from January 2014 to December 2019 from our center. Intraoperative deaths were excluded. Recipient, donor clinical and demographic data were collected. We developed risk-adjusted models to assess the effect of statin use on the occurrence of VTE, hepatic artery complications (HACs), graft failure, and death, accounting for clinical covariates and competing risks. A total of 672 OLT recipients were included in the analysis. Of this cohort, 11.9% (n = 80) received statin therapy. A total of 47 patients (7.0%) had VTE events. HACs occurred in 40 patients (6.0%). A total of 42 (6.1%) patients experienced graft loss, whereas 9.1% (n = 61) of the cohort died during the study interval. Eighty OLT recipients (29.8%) were treated with statins. In the statin treated group, 0% of patients had VTE versus 7.9% of those not on statins (P = 0.02). HACs were identified in 1.2% of...Continue Reading

References

Sep 7, 1995·The New England Journal of Medicine·J A KobashigawaG A Cogert
Aug 3, 2001·Archives of Internal Medicine·J G RayA Laupacis
Feb 19, 2002·British Journal of Clinical Pharmacology·Chen-Chang YangHershel Jick
Jul 15, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Krista L Lentine, Daniel C Brennan
Jan 27, 2005·The American Journal of Cardiology·Audrey H WuKevin D O'Brien
Apr 30, 2005·Seminars in Vascular Medicine·Jon A Kobashigawa
Sep 7, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ivan StojanovicO H Frazier
Nov 24, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H HoldaasUNKNOWN Assessment of LEscol in Renal Transplantation (ALERT) Study Investigators
May 13, 2006·Journal of Thrombosis and Haemostasis : JTH·D PoliD Prisco
Mar 21, 2007·Journal of Thrombosis and Haemostasis : JTH·I A NaessJ Hammerstrøm
Nov 11, 2008·The New England Journal of Medicine·Paul M RidkerUNKNOWN JUPITER Study Group
Nov 28, 2008·Journal of Thrombosis and Haemostasis : JTH·A S RamcharanC J M Doggen
Dec 23, 2008·The American Journal of Gastroenterology·Kirstine Kobberøe SøgaardHenrik Toft Sørensen
Mar 31, 2009·The New England Journal of Medicine·Robert J GlynnPaul M Ridker
Apr 17, 2009·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Zhi-Jiang ZhangKevin E Kip
Jan 28, 2010·The American Journal of Medicine·Danai KhemasuwanGlenn Eiger
Apr 29, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Qian Zhou, James K Liao
Jul 14, 2010·Journal of the American College of Cardiology·Samuel Z Goldhaber
Aug 19, 2010·International Journal of Clinical Practice·V AgarwalC I Coleman
Oct 16, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Vivek N AhyaSangeeta Bhorade
Jul 12, 2011·Journal of Hepatology·Omar Massoud, Russell H Wiesner
Jul 4, 2012·The Journal of Clinical Investigation·Nigel Mackman
Jul 5, 2012·Circulation·Georg Marcus FröhlichFrank Ruschitzka
Jul 11, 2012·Clinical Transplantation·Jennifer T ThibodeauMark H Drazner
Sep 17, 2013·Transplantation Proceedings·P TodeschiniS Stefoni
Jan 29, 2014·Surgery·James C IannuzziFergal J Fleming
May 28, 2014·Thrombosis Research·Jeffrey I Zwicker
May 31, 2014·World Journal of Gastroenterology : WJG·Moustafa Mabrouk MouradSimon R Bramhall
Dec 17, 2014·Transplantation Proceedings·A AnnamalaiA Klein
Jan 13, 2015·Transplantation Reviews·Berta Sáez-GiménezAntonio Roman
May 29, 2015·World Journal of Hepatology·Abdullah A AlgarniSimon R Bramhall
Dec 29, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zobair M YounossiMark Wymer
Feb 9, 2016·American Journal of Surgery·Valerie EmuakhagbonChristopher M Jones
Apr 12, 2016·Journal of Thrombosis and Haemostasis : JTH·N L SmithB M Psaty

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