PMID: 15243219Jul 10, 2004Paper

Statin therapy in the elderly

Current Opinion in Lipidology
Moira M B Mungall, A Gaw

Abstract

The clinical efficacy and safety of statin therapy have been well established from a series of large-scale, randomized controlled trials. These trials, however, have predominantly recruited patients under the age of 70 years. As a consequence, the use of statins in older patients has remained controversial. The results of the first trial to look exclusively at the elderly--the Prospective Study of Pravastatin in the Elderly at Risk--have added enormously to our understanding of the use of statins in the elderly. These findings, together with those from the large elderly cohort within the Heart Protection Study and the smaller elderly subgroups within the other major statin trials, have forced us to re-evaluate any systematic exclusion of elderly patients from statin therapy. The collective evidence now strongly supports the use of statins in the at-risk elderly population.

References

Dec 5, 1998·The New England Journal of Medicine·UNKNOWN Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
Sep 21, 2002·Lancet·Duncan M Geddes
Nov 30, 2002·Lancet·James ShepherdUNKNOWN PROSPER study group. PROspective Study of Pravastatin in the Elderly at Risk
Dec 31, 2002·Controlled Clinical Trials·Jerry AvornUNKNOWN Outcomes Research Working Group and the PROSPER Study Group
Jan 4, 2003·Stroke; a Journal of Cerebral Circulation·Wolfgang LalouschekUNKNOWN Vienna Stroke Study Group
Feb 8, 2003·Stroke; a Journal of Cerebral Circulation·Frank M Faraci
Mar 19, 2003·Drugs & Aging·Moira M B MungallJames Shepherd
May 20, 2003·Journal of the American Geriatrics Society·Wilbert S Aronow
Jun 20, 2003·British Journal of Clinical Pharmacology·David WilliamsJohn Feely
Jul 18, 2003·The American Journal of Cardiology·John A Farmer, Antonio M Gotto
Jul 31, 2003·The American Journal of Geriatric Cardiology·Eric BruckertSylvie Dejager
Aug 21, 2003·The British Journal of Ophthalmology·G McGwinR J Crain

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