Statin Therapy Is Associated with Reduced Risk of Peptic Ulcer Disease in the Taiwanese Population

Frontiers in Pharmacology
Chun-Jung LinChia-Hung Kao

Abstract

Although statin use may affect the severity of chronic gastritis and gastric cancer, no data exists about the relationship between statin therapy and risk of peptic ulcer disease (PUD) in patients. We investigated the effect of statin use and the incidence of PUD from the Taiwan National Health Insurance Research Database (NHIRD). A total of 35,194 patients records for medical claims were enrolled. We performed a population-based case-control analysis to compare the incidence of PUD in patients who were prescribed statins and that in patients who were not. In the univariate logistic analysis, we found that statin was not significant risk of PUD. However, a multivariate model indicates that satin use was significantly associated with a reduced risk of PUD (adjusted odds ratio [aOR] = 0.87, 95% CI = 0.82-0.93, P < 0.001). The cumulative defined daily dose (DDD) was analyzed. Patients who prescribed fluvastatin ≥280 DDD, atorvastatin ≥200 DDD, and pravastatin ≥130 DDD dramatically decreased risk for PUD (aOR = 0.58, 0.67, and 0.71; 95% CI = 0.46-0.74, 0.57-0.78, and 0.56-0.91, respectively). Our results showed that statin therapy reduced the risk of PUD and this was associated with the high cumulative DDD of prescribed statins. Th...Continue Reading

References

Jan 19, 2000·Circulation·D J MaronM F Linton
Dec 2, 2000·Nature Medicine·B KwakF Mach
Jan 7, 2005·The New England Journal of Medicine·Steven E NissenUNKNOWN Reversal of Atherosclerosis with Aggressive Lipid Lowering (REVERSAL) Investigators
Apr 4, 2007·Digestive Diseases and Sciences·Masanori YamatoTetsuo Arakawa
Jun 27, 2007·Journal of Gastroenterology and Hepatology·Mohammad TariqRamiz Al Swailam
Dec 19, 2007·The Journal of Antimicrobial Chemotherapy·S Jerwood, J Cohen
Nov 11, 2008·The New England Journal of Medicine·Paul M RidkerUNKNOWN JUPITER Study Group
Aug 18, 2009·Lancet·Peter MalfertheinerKenneth E L McColl
Nov 16, 2010·Helicobacter·William NseirNimer Assy
Feb 26, 2011·Pharmacoepidemiology and Drug Safety·Ching-Lan ChengMing Liang Lai
Mar 31, 2011·Nature Reviews. Neuroscience·Gilbert Di Paolo, Tae-Wan Kim
Aug 17, 2011·The American Journal of Gastroenterology·Hui-Fen ChiuChun-Yuh Yang
Jan 25, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yu-Tse TsanPau-Chung Chen
Jan 30, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Siddharth SinghPrasad G Iyer
Apr 9, 2013·The Journal of Antimicrobial Chemotherapy·William NseirRaymond Farah
Apr 20, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P P Singh, S Singh
May 24, 2014·The Journal of Antimicrobial Chemotherapy·Ciaran SkerryPetros C Karakousis
Aug 1, 2015·European Journal of Internal Medicine·Anning FengChia-Hung Kao
Feb 26, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ashwin N AnanthakrishnanIsaac Kohane
Feb 2, 2017·Frontiers in Cellular and Infection Microbiology·Wei-Chih LiaoChih-Ho Lai
Jul 1, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P P Singh, S Singh

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Citations

Jan 17, 2019·Journal of Clinical Medicine·Yi-Hsing ChenChih-Ho Lai
Oct 16, 2019·Oncology Letters·Pattaya SeereeSupeecha Kumkate
Mar 28, 2018·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Wei-Syun Hu, Cheng-Li Lin
Dec 19, 2018·Medicine·Monica PanteaSimona Băţagă

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