Statin treatment and adherence to national cholesterol guidelines after ischemic stroke

Neurology
B OvbiageleVISP Study Investigators

Abstract

National cholesterol guidelines have defined high vascular risk individuals as those who could potentially benefit most from statin therapy. The authors aimed to determine the rate of statin use, its predictors, and the achievement of national guideline target lipid goals among ischemic stroke survivors. The authors abstracted data from the Vitamin Intervention for Stroke Prevention (VISP) study database from the United States and Canada to incorporate into algorithms for initiating statin therapy according to the National Cholesterol Education Program (NCEP) guidelines for high-risk individuals. The authors applied these algorithms to all study subjects. Univariate as well as multivariate associations for target lipid levels and statin implementation were then evaluated utilizing pertinent demographic, clinical, and laboratory data. Of 2,894 subjects in the analysis dataset, 38% were women; 71% were recruited in the United States and 29% in Canada. Of 769 high-risk subjects, 262 (34%) had a low-density lipoprotein (LDL) level > or =130 mg/dL and 124 of these (47%) were not on statin. Among those high-risk persons on statin treatment, only 42% had an LDL < or =100 mg/dL. Subjects in the overall cohort were more likely to be on ...Continue Reading

Citations

Oct 13, 2006·Current Treatment Options in Neurology·Richard A Bernstein
Dec 1, 2006·The New England Journal of Medicine·Jay S Cohen
Aug 11, 2006·The New England Journal of Medicine·David M Kent
Dec 21, 2013·The Permanente Journal·Kari L OlsonJohn A Merenich
Mar 22, 2014·BMC Neurology·Isabella CanaveroUNKNOWN Lombardia Stroke Registry (LSR) investigators
Nov 28, 2013·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Jiann-Shing JengUNKNOWN Taiwanese Secondary Prevention for Patients with AtheRosCLErotic Disease (T-SPARCLE) Registry Investigators
Aug 30, 2008·Journal of the Neurological Sciences·Bruce Ovbiagele
Jul 1, 2008·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Stanley TuhrimMark Chassin
Jan 22, 2008·European Journal of Internal Medicine·Luis Castilla GuerraMaría Dolores Jiménez Hernández
Sep 22, 2006·Lancet Neurology·Graeme J Hankey
Jan 17, 2012·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A HøghS P Johnsen
Dec 10, 2014·Nature Reviews. Neurology·Jong-Ho Park, Bruce Ovbiagele
Jul 28, 2007·American Journal of Medical Quality : the Official Journal of the American College of Medical Quality·Prasuna JamiBernardo J Reyes
May 29, 2010·Stroke; a Journal of Cerebral Circulation·Bruce OvbiageleJeffrey L Saver
Mar 31, 2007·Stroke; a Journal of Cerebral Circulation·Deborah A LevineJeroan J Allison
Oct 11, 2014·Stroke; a Journal of Cerebral Circulation·Gustavo SaposnikUNKNOWN AHA Get-with-the-Guidelines Stroke
Aug 9, 2008·Stroke; a Journal of Cerebral Circulation·Björn WettermarkMia von Euler
Sep 23, 2014·Stroke; a Journal of Cerebral Circulation·Jong-Ho ParkBruce Ovbiagele
Dec 31, 2011·Stroke; a Journal of Cerebral Circulation·Kaare Haurvig PalnumSøren Paaske Johnsen
Feb 14, 2009·Stroke; a Journal of Cerebral Circulation·Gustavo SaposnikUNKNOWN Stroke Outcome Research Canada Working Group
Apr 14, 2007·Stroke; a Journal of Cerebral Circulation·Seemant Chaturvedi
Feb 3, 2007·Stroke; a Journal of Cerebral Circulation·Bruce Ovbiagele, Jeffrey L Saver
Apr 5, 2008·Stroke; a Journal of Cerebral Circulation·Bruce OvbiageleJeffrey L Saver
Sep 12, 2009·Stroke; a Journal of Cerebral Circulation·Alejandro A Rabinstein

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