Statin use after renal transplantation: a systematic quality review of trial-based evidence

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Krista L Lentine, Daniel C Brennan

Abstract

HMG-CoA reductase inhibitor (statin) therapy reduces cardiovascular risk in the general population and may modulate rejection in solid organ transplant recipients. We assessed whether current clinical evidence supports the use of statins to improve cardiac and/or renal outcomes after kidney transplantation. We performed a systematic review of randomized, controlled intervention trials of statins among renal allograft recipients. Clinical trials published between January 1, 1993 and January 1, 2004 were identified by systematic search of electronic databases. Eligible studies measured the impact of therapy on acute allograft rejection, surrogates of cardiovascular risk and/or cardiovascular morbidity and mortality. We abstracted descriptive summaries of trial design elements and primary effect estimates, and assessed trial quality with a standardized quality evaluation tool. Thirteen eligible trials were identified. Statin therapy was associated with less acute allograft rejection in two early studies but was ineffective in three subsequent, larger trials. Therapeutic benefit was also seen in six of seven small studies that evaluated cardiovascular risk surrogates. Statin use did not significantly alter the primary composite out...Continue Reading

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Citations

Aug 26, 2006·Nature Clinical Practice. Nephrology·Sabine Steffens, François Mach
Oct 23, 2013·The Journal of Experimental Medicine·Fadi G Lakkis, Timothy R Billiar
Dec 9, 2004·Current Opinion in Nephrology and Hypertension·Justin C Mason
Jan 10, 2006·Seminars in Dialysis·Elizabeth A Kendrick, Connie L Davis
Nov 25, 2006·Kidney & Blood Pressure Research·Kai LopauChristoph Wanner
Feb 24, 2006·Journal of Clinical Pharmacology·Arthur J BergmanJohn F Paolini
Aug 2, 2005·International Journal of Cardiology·Khalid AlmutiRobert J Ostfeld
May 13, 2006·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·K I ParaskevasD P Mikhailidis
Jan 29, 2014·The Cochrane Database of Systematic Reviews·Suetonia C PalmerGiovanni Fm Strippoli
Mar 23, 2013·Journal of Atherosclerosis and Thrombosis·Daisuke Koya, Vito M Campese
May 9, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Peter E FrascoAmit K Mathur

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