Statin use and high-dose statin use after ischemic stroke in the UK: a retrospective cohort study

Clinical Epidemiology
Zhirong YangJonathan Mant

Abstract

Background: Trial evidence supports statin use after ischemic stroke and recent American, European and British guidelines recommend high-intensity statins for this indication. Limited data are available describing current statin use among these patients in unselected settings. We conducted a cohort study to examine secular trends and factors associated with statin use and dose following ischemic stroke. Methods: A retrospective cohort study of patients with first ischemic stroke between 2000 and 2014 was conducted using the Clinical Practice Research Datalink (CPRD). Proportions of statin users and high-intensity statin users within 2 years after stroke were estimated for each calendar year. We used Cox regression models to explore potential factors associated with statin use and Poisson regression models to calculate risk ratios for the use of a high-intensity statin. Results: A total of 80,442 patients with first stroke were analyzed. The proportion using statins within 2 years after stroke increased from 25% in 2000 to 70% in 2006 and remained at about 75% through 2014. Among post-stroke statin users, high-intensity use accounted for approximately 15% between 2004 and 2011 and then increased to almost 35% in 2014. Older pati...Continue Reading

Citations

Oct 5, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Dominik LautschSwapnil N Rajpathak
Jun 20, 2020·Therapeutic Advances in Neurological Disorders·Chaohua CuiLi He
Jul 7, 2020·Arquivos de neuro-psiquiatria·Bruno Kusznir Vitturi, Rubens José Gagliardi

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