Statin Use and Knee Osteoarthritis Outcomes: A Longitudinal Cohort Study

Arthritis Care & Research
Nicola VeroneseJean-Yves Reginster

Abstract

Statins have several pleiotropic effects, but the literature regarding the possible relationship between use of statins and outcomes in knee osteoarthritis (OA) is limited. The aim of this study was to investigate whether statin use is associated with a lower risk of radiographic OA (ROA), radiographic symptomatic knee OA, and pain in North American individuals. A total of 4,448 community-dwelling adults from the Osteoarthritis Initiative were followed for 4 years. Statin use (including the time from baseline and the type of statin) was defined through self-report information and confirmed by a trained interviewer. Knee OA outcomes included incident ROA, symptomatic knee OA (new onset of a combination of a painful knee and ROA), and knee pain worsening (i.e., a Western Ontario and McMaster Universities Osteoarthritis Index difference between baseline and each annual examination ≥14%). At baseline, 1,127 participants (25.3% of the total population) used statins. Based on a multivariable Poisson regression analysis with robust variance estimators, any use of statins was not associated with a lower risk of pain worsening (relative risk [RR] 0.97, 95% confidence interval [95% CI] 0.93-1.02), incident ROA, or symptomatic knee OA. Ho...Continue Reading

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Citations

Feb 25, 2020·Expert Review of Clinical Pharmacology·Joseph V PergolizziPeter Magnusson
Jun 20, 2020·The Journal of International Medical Research·Kazuhiko Hashimoto, Masao Akagi
Jun 27, 2021·Bone·Ioanna PapathanasiouAspasia Tsezou

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