Statin use and Parkinson's disease in Denmark.

Movement Disorders : Official Journal of the Movement Disorder Society
Beate RitzSoren Friis

Abstract

The objective of this study was to investigate whether statin (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor) use is associated with risk of Parkinson's disease (PD) in Denmark. We identified 1,931 patients with a first time diagnosis of PD reported in hospital or outpatient clinic records between 2001 and 2006. We density matched to these patients 9,651 population controls by birth year and sex relying on the Danish population register. For every participant, we identified pharmacy records of statin and anti-Parkinson drug prescriptions since 1995 and before index date from a prescription medication use database for all Danish residents. Whenever applicable, the index dates for cases and their corresponding controls were advanced to the date of first recorded prescription for anti-Parkinson drugs. In our primary analyses, we excluded all statin prescriptions 2-years before PD diagnosis. Employing logistic regression adjusting for age, sex, diagnosis of chronic obstructive pulmonary disease, and Charlson comorbidity, we observed none to slightly inverse associations between PD diagnosis and statin prescription drug use. Inverse associations with statin use were only observed for short-term (<or=1 yrs) statin users (...Continue Reading

References

Jan 1, 1987·Journal of Chronic Diseases·M E CharlsonR G Douglas
Jan 1, 1997·Molecular Aspects of Medicine·S A MortensenM Rohde
Jul 7, 2001·Journal of the Neurological Sciences·B Cucchiara, S E Kasner
Dec 11, 2002·European Heart Journal·P Di NapoliR De Caterina
Dec 20, 2002·Human Molecular Genetics·Clotilde LevecqueMarie-Christine Chartier-Harlin
Apr 1, 2003·Annals of Neurology·Stephane Hunot, E C Hirsch
Mar 1, 2005·Parkinsonism & Related Disorders·Abraham LiebermanRobert Myerburg
Jun 14, 2005·Redox Report : Communications in Free Radical Research·Sarika SinghM Dikshit
Aug 15, 2006·American Journal of Epidemiology·Lonneke M L de LauMonique M B Breteler
Dec 21, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Xuemei HuangCharles Poole
Jun 9, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Lonneke M L de LauMonique M B Breteler
Sep 1, 2007·Neurology·Kelly Claire SimonAlberto Ascherio
Jan 11, 2008·Neurology·Angelika D WahnerBeate Ritz
Feb 6, 2008·Journal of Neurochemistry·Pazit Bar-OnEliezer Masliah
Nov 19, 2008·Parkinsonism & Related Disorders·Ronald F Pfeiffer
Apr 3, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Xuemei HuangG Webster Ross
Apr 9, 2008·Free Radical Biology & Medicine·Steven R Danielson, Julie K Andersen
Apr 11, 2008·Neurology·G HuJ Tuomilehto
Apr 22, 2008·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Claudia BeckerChristoph R Meier
Oct 1, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Ali SamiiMahyar Etminan
Nov 4, 2008·Nature Clinical Practice. Neurology·Claire Henchcliffe, M Flint Beal

❮ Previous
Next ❯

Citations

Mar 14, 2012·Archives of Neurology·Xiang GaoAlberto Ascherio
Jul 24, 2012·Journal of Neurology·Krishna UndelaDipika Bansal
Oct 24, 2014·The International Journal of Neuroscience·Xiaoyan GuoHui-Fang Shang
Dec 3, 2014·Nature Reviews. Neurology·Dilan Athauda, Thomas Foltynie
May 2, 2016·Behavioural Brain Research·Zhiguo ShengMeini Kang
Apr 4, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Guodong LiuXuemei Huang
Jan 10, 2019·Cells·Helena XicoyGerard J M Martens
Apr 3, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Su-Min JeongDong Wook Shin
Nov 21, 2017·Journal of Parkinson's Disease·Honglei Chen
Feb 3, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Xuemei HuangHonglei Chen
Jun 27, 2017·NPJ Parkinson's Disease·C J H M KlemannG Poelmans
Aug 17, 2016·Pharmacoepidemiology and Drug Safety·Katsiaryna BykovJoshua J Gagne
Feb 26, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A J ClarkN H Rod
Jan 16, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Chin-Hsien LinRuey-Meei Wu
Jul 22, 2011·Trends in Neurosciences·Marta Valenza, Elena Cattaneo

❮ Previous
Next ❯

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