Statin Use and Prostate Cancer Aggressiveness: Results from the Population-Based North Carolina-Louisiana Prostate Cancer Project

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Emma H AllottJeannette T Bensen

Abstract

Although statin use has been associated with reduced prostate cancer aggressiveness, the impact of race and patient characteristics on this association is not well understood. We examined the association between statin use and prostate cancer aggressiveness in Caucasians (CA) and African Americans (AA) and explored effect modification by health-seeking behaviors associated with statin use. Of 1,930 cases from The North Carolina-Louisiana Prostate Cancer Project, 344 (18%) were classified as aggressive based on clinical criteria. Utilizing nonaggressive cases as referent, logistic regression was used to examine the association between statin use and prostate cancer aggressiveness, overall and stratified by race. Smoking and prostate cancer screening were examined as effect modifiers of this association. There was an inverse association between statin use and prostate cancer aggressiveness [OR, 0.74; 95% confidence interval (CI), 0.56-0.96], with comparable effect estimates in both races. Although not statistically significant, statin use was associated with reduced ORs for aggressive prostate cancer in never-screened men (OR, 0.79; 95% CI, 0.45-1.39), men screened at low/recommended frequency (≤once/year; OR, 0.66; 95% CI, 0.41-...Continue Reading

References

Feb 16, 2002·Journal of the American Dietetic Association·Frances E ThompsonRegina G Ziegler
Jan 5, 2006·JAMA : the Journal of the American Medical Association·Krista M DaleC Michael White
Nov 30, 2006·International Journal of Cancer. Journal International Du Cancer·Danielle R L Browning, Richard M Martin
Dec 21, 2006·Journal of the National Cancer Institute·Elizabeth A PlatzEdward Giovannucci
Nov 6, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Elizabeth A Platz
Nov 17, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Teemu J MurtolaAnssi Auvinen
May 21, 2008·International Journal of Cancer. Journal International Du Cancer·Stefanos BonovasNikolaos M Sitaras
Aug 19, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jaana KuoppalaEero Pukkala
Oct 30, 2008·Journal of the National Cancer Institute·Robert J HamiltonStephen J Freedland
Jun 30, 2009·Cancer Causes & Control : CCC·Ke Zu, Edward Giovannucci
Nov 6, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Elizabeth A PlatzAlan R Kristal
Apr 10, 2010·Expert Opinion on Drug Safety·Denise M BoudreauJeanene Johnson
Aug 4, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven L ChangJoseph C Presti
Apr 19, 2011·Journal of the National Cancer Institute·Wildon R FarwellJ Michael Gaziano
Sep 15, 2011·Cancer Causes & Control : CCC·Alison M MondulDemetrius Albanes
Jul 25, 2012·Current Opinion in Pharmacology·Kristine PeltonKeith R Solomon
Oct 11, 2012·PloS One·Dipika BansalFabrizio Schifano
Dec 12, 2012·European Urology·Emma H AllottStephen J Freedland
Apr 10, 2013·Prostate Cancer and Prostatic Diseases·S J FreedlandR S Rittmaster
Nov 6, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Oriana YuLaurent Azoulay
Nov 19, 2013·Journal of the American College of Cardiology·Neil J StoneUNKNOWN American College of Cardiology/American Heart Association Task Force on Practice Guidelines
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Feb 13, 2014·The Journal of Urology·Elizabeth A PlatzAlan R Kristal
Mar 13, 2014·Journal of Oncology Practice·UNKNOWN American Society of Clinical Oncology
Aug 21, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tammy HoStephen J Freedland
May 28, 2015·The Prostate·Elizabeth D KantorLisa B Signorello

❮ Previous
Next ❯

Citations

Nov 3, 2016·Nature Reviews. Urology·Mahmoud A AlfaqihStephen J Freedland
May 3, 2018·The Prostate·Emma H AllottJeannette T Bensen
May 4, 2018·Future Oncology·Martyna ZaleskaJacek Bil
Feb 9, 2018·Oncotarget·Alfredo Caro-MaldonadoArkaitz Carracedo
Nov 22, 2016·Lipid Insights·Jonathan T DaviesHollie I Swanson
Jan 22, 2019·Frontiers in Pharmacology·Huanbiao MoHoda Yeganehjoo
Oct 10, 2020·Journal of Experimental & Clinical Cancer Research : CR·Federica IannelliAlfredo Budillon
Nov 23, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Emma H AllottLorelei A Mucci
Sep 15, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Mazaher AhmadiSaeid Ghavami

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.