Oct 31, 2007

Statin use and recurrence of atrial fibrillation after successful cardioversion

American Heart Journal
Karin H HumphriesCARAF Investigators

Abstract

Statins have important pleiotropic effects and have been shown to reduce vascular inflammation and the incidence of atrial fibrillation (AF) after cardiac surgery. The role of statins in patients with existing AF is poorly understood. We examined the effect of statins on recurrence of AF in patients after successful cardioversion. Statin use and documented recurrence of AF after successful cardioversion were evaluated in 625 patients with new onset AF who were followed prospectively in the Canadian Registry of Atrial Fibrillation. Logistic regression was used to model the effect of statin use on the recurrence of AF at 1 year while adjusting for potential confounders including concurrent medications. In a predominantly male population (62%) with median age 63 years, 12.3% were on statins at baseline. Overall, 32.5% had documented recurrence of AF at 1 year; 23.4% in patients on statins compared to 33.8% in those not on statins (P = .07). After adjustment for baseline differences and concomitant beta-blocker use, statin use was associated with a 74% reduction in AF recurrence, but only in statin users on beta-blockers (OR 0.26, 95% CI 0.10-0.66); statin users not on beta-blockers (OR 1.07, 95% CI 0.44-2.58). In an observational ...Continue Reading

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Mentioned in this Paper

EEF1A2
Observational Study
Vascular Inflammations
Discipline of Heart Surgery
Digoxin
Pravastatin
Anti-Arrhythmia Agents
Recurrent Malignant Neoplasm
Antiarrhythmic [EPC]
Sinus - General Anatomical Term

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