Statin use and risk of developing diabetes: results from the Diabetes Prevention Program.

BMJ Open Diabetes Research & Care
Jill P CrandallMarinella Temprosa

Abstract

Several clinical trials of cardiovascular disease prevention with statins have reported increased risk of type 2 diabetes (T2DM) with statin therapy. However, participants in these studies were at relatively low risk for diabetes. Further, diabetes was often based on self-report and was not the primary outcome. It is unknown whether statins similarly modify diabetes risk in higher risk populations. During the Diabetes Prevention Program Outcomes Study (n=3234), the long-term follow-up to a randomized clinical trial of interventions to prevent T2DM, incident diabetes was assessed by annual 75 g oral glucose tolerance testing and semiannual fasting glucose. Lipid profile was measured annually, with statin treatment determined by a participant's own physician outside of the protocol. Statin use was assessed at baseline and semiannual visits. At 10 years, the cumulative incidence of statin initiation prior to diabetes diagnosis was 33%-37% among the randomized treatment groups (p=0.36). Statin use was associated with greater diabetes risk irrespective of treatment group, with pooled HR (95% CI) for incident diabetes of 1.36 (1.17 to 1.58). This risk was not materially altered by adjustment for baseline diabetes risk factors and pot...Continue Reading

Associated Clinical Trials

References

Mar 23, 1999·Nature Medicine·P Brown
Feb 8, 2002·The New England Journal of Medicine·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
Aug 29, 2006·Diabetes Care·Richard F HammanJudith Wylie-Rosett
Dec 29, 2006·Journal of Atherosclerosis and Thrombosis·Mayumi IshikawaHitoshi Shimano
Nov 11, 2008·The New England Journal of Medicine·Paul M RidkerUNKNOWN JUPITER Study Group
Dec 6, 2008·American Journal of Hypertension·Yong MaUNKNOWN Diabetes Prevention Program Research Group
Oct 2, 2009·Diabetes Care·Swapnil N RajpathakPaul M Ridker
Nov 17, 2009·Diabetes Research and Clinical Practice·William L BakerCraig I Coleman
Apr 29, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Qian Zhou, James K Liao
Apr 2, 2011·Journal of the American College of Cardiology·David D WatersPhilip Barter
Jun 23, 2011·JAMA : the Journal of the American Medical Association·David PreissKausik K Ray
Jan 11, 2012·Archives of Internal Medicine·Annie L CulverYunsheng Ma
Nov 1, 2014·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·D ThakkerJ S Shaikh
Jun 10, 2016·Pharmacoepidemiology and Drug Safety·Divyesh ThakkerAnuradha Malik

❮ Previous
Next ❯

Citations

Nov 16, 2017·Postgraduate Medicine·Kevin C MakiMelvyn W Kramer
Feb 28, 2018·Journal of Clinical Pharmacy and Therapeutics·S Kato, M Miura
Apr 17, 2018·Journal of Diabetes·Richard Ofori-AsensoDanny Liew
Nov 8, 2018·BMJ : British Medical Journal·Robin E Ferner, Patricia McGettigan
Apr 13, 2018·Journal of Community Health·Kyle ShaakBeth A Careyva
May 1, 2019·Current Atherosclerosis Reports·Rafael Carmena, D John Betteridge
Jun 14, 2019·Post Reproductive Health·John C Stevenson
Mar 1, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Rebecca N JeromeJill M Pulley
Oct 8, 2019·Journal of Atherosclerosis and Thrombosis·Kouji KajinamiUNKNOWN Statin Intolerance Clinical Guide Working Group; The Japan Society of Hepatology, Japanese Society of Neurology, Japan Ather
Jun 26, 2018·Current Diabetes Reports·Rona J Strawbridge, Natalie R van Zuydam
Mar 30, 2019·Cardiovascular Diabetology·Ricardo J Esper, Roberto A Nordaby
Sep 3, 2019·Expert Review of Clinical Pharmacology·Srikanth YandrapalliWilbert S Aronow
Sep 10, 2019·European Heart Journal·Francesco CosentinoUNKNOWN ESC Scientific Document Group
Sep 19, 2020·Biomedicines·Miljenko Valentin PanajatovicJamal Bouitbir
Jul 8, 2020·International Journal of Molecular Sciences·Unai Galicia-GarciaCésar Martín
May 1, 2018·Current Opinion in Lipidology·Sei HiguchiRebecca A Haeusler
Jan 20, 2021·Future Cardiology·Vishnu Priya Pulipati, Michael H Davidson
Jun 3, 2021·International Journal of Molecular Sciences·Miljenko V PanajatovicJamal Bouitbir
Jul 3, 2021·Cells·Rajakrishnan Veluthakal, Debbie C Thurmond
Sep 2, 2021·Journal of Cardiovascular Translational Research·Soo Ghee YeohTheam Soon Lim
Aug 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Vajiheh JahaniGholamreza Karimi

❮ Previous
Next ❯

Software Mentioned

SAS

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.