Abstract
Limited clinical and epidemiologic data suggest that statins may improve the outcomes of hepatocellular carcinoma (HCC), which has poor prognosis. We identified 1,036 stage I or II HCC patients, diagnosed between 2007 and 2009, through the linked Surveillance, Epidemiology, and End Results (SEER) Program and Medicare claims database. Of these, 363 patients were using statin either at the time of their HCC diagnosis or afterwards. We conducted multivariable Cox regression analysis to estimate the time-dependent effect of statin on survival. The analysis included age, sex, resection, transarterial chemoembolization, transplantation, cirrhosis, cardiovascular disease, diabetes, dyslipidemia, and hepatitis B and C. Over a median follow-up time of 21 months, 584 HCC patients died. Statin users had a longer median survival compared with nonusers: 23.9 versus 18.9 months (P = 0.047). However, after accounting for immortal time bias and confounding, statin use was not associated with survival (HR, 0.98; 95% confidence interval, 0.80-1.20). The associations did not vary by hepatitis C or intensity of statin use. Statin treatment after HCC diagnosis was not associated with survival in elderly patients with stage I/II disease. Our study o...Continue Reading
References
Mar 24, 1998·Trends in Pharmacological Sciences·B A Hamelin, J Turgeon
May 20, 1999·Transplantation Proceedings·J M LäufferM W Büchler
Apr 5, 2001·British Journal of Cancer·S KawataY Matsuzawa
Dec 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jin YeMichael Gale
Sep 7, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ju-Seog LeeSnorri S Thorgeirsson
Mar 22, 2006·The Oncologist·Susan Burdette-Radoux, Hyman B Muss
Aug 15, 2006·Cancer Cell·Anuradha BudhuXin Wei Wang
Dec 7, 2007·American Journal of Epidemiology·Samy Suissa
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
May 14, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Leen DelangJohan Neyts
Jun 23, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stephen A HarrisonMark S Sulkowski
Jan 1, 2009·Therapeutic Advances in Gastroenterology·Kathleen E Corey, Daniel S Pratt
Oct 16, 2012·Gastroenterology·Siddharth SinghWilliam Sanchez
Mar 20, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yu-Tse TsanPau-Chung Chen
Oct 2, 2013·Nature Reviews. Clinical Oncology·Naomi Gronich, Gad Rennert
Nov 14, 2013·Journal of the American Pharmacists Association : JAPhA
Nov 19, 2013·Journal of the American College of Cardiology·Neil J StoneUNKNOWN American College of Cardiology/American Heart Association Task Force on Practice Guidelines
Jun 24, 2014·International Journal of Molecular Sciences·Atsushi TakaiXin W Wang
Jul 24, 2014·Gut·Gianluigi GiannelliGiuseppe Palasciano
Citations
Feb 28, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael J SecklAllan Hackshaw
Apr 21, 2017·Cancers·Hiroshi Kobayashi
May 4, 2018·Future Oncology·Martyna ZaleskaJacek Bil
Mar 11, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Robert SchierwagenJonel Trebicka
Apr 10, 2020·Journal of Clinical Gastroenterology·Samuel O AntwiTushar Patel
Aug 4, 2016·Oncotarget·Shuncong WangHaiqing Ma
Jun 20, 2020·Technology in Cancer Research & Treatment·Yue ChangHai Li
Jul 29, 2016·World Journal of Gastroenterology : WJG·Martin JanickoPeter Jarcuska
Mar 13, 2020·Bioscience Reports·Xiaofei LiYongtao Hu
Jan 7, 2021·European Journal of Gastroenterology & Hepatology·Jianfeng Wang, Xiaogang Li