Statin Use and Survival with Early-Stage Hepatocellular Carcinoma

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Christie JeonVinay Sundaram

Abstract

Limited clinical and epidemiologic data suggest that statins may improve the outcomes of hepatocellular carcinoma (HCC), which has poor prognosis. We identified 1,036 stage I or II HCC patients, diagnosed between 2007 and 2009, through the linked Surveillance, Epidemiology, and End Results (SEER) Program and Medicare claims database. Of these, 363 patients were using statin either at the time of their HCC diagnosis or afterwards. We conducted multivariable Cox regression analysis to estimate the time-dependent effect of statin on survival. The analysis included age, sex, resection, transarterial chemoembolization, transplantation, cirrhosis, cardiovascular disease, diabetes, dyslipidemia, and hepatitis B and C. Over a median follow-up time of 21 months, 584 HCC patients died. Statin users had a longer median survival compared with nonusers: 23.9 versus 18.9 months (P = 0.047). However, after accounting for immortal time bias and confounding, statin use was not associated with survival (HR, 0.98; 95% confidence interval, 0.80-1.20). The associations did not vary by hepatitis C or intensity of statin use. Statin treatment after HCC diagnosis was not associated with survival in elderly patients with stage I/II disease. Our study o...Continue Reading

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Citations

Feb 28, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael J SecklAllan Hackshaw
Apr 21, 2017·Cancers·Hiroshi Kobayashi
May 4, 2018·Future Oncology·Martyna ZaleskaJacek Bil
Mar 11, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Robert SchierwagenJonel Trebicka
Jun 20, 2020·Technology in Cancer Research & Treatment·Yue ChangHai Li
Jul 29, 2016·World Journal of Gastroenterology : WJG·Martin JanickoPeter Jarcuska
Jan 7, 2021·European Journal of Gastroenterology & Hepatology·Jianfeng Wang, Xiaogang Li

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