Statin use does not prevent recurrent adenomatous polyp formation in a VA population.

Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology
Nikki Parker-RayRichard M Hoffman

Abstract

To evaluate whether statin use was associated with recurrent adenomatous polyps. We conducted a retrospective cohort study. We used electronic health records to evaluate veterans who underwent polypectomy between January 1, 1999 and December 31, 2001 and surveillance colonoscopy by December 2006. We obtained data on pathology, demographics, body mass index, comorbidity, habits, family history, and medications. We used multivariate proportional hazards regression models to analyze data. We evaluated 197 eligible patients from among 821 who underwent colonoscopy during this period; their mean (SD) age was 63.1 (8.8) years, 192 (98%) were men, and 80 (41%) non-Hispanic white. Surveillance colonoscopy was performed after a mean (SD) 1207 (452) days and 108 (55%) patients had recurrent adenomas. During follow-up, 88 (47%) of patients received statins, but use was not protective against recurrent adenomas (hazard ratio = 1.36, 95% CI 0.35-8.27). Only number of polyps at initial colonoscopy predicted recurrent adenomas (1.98, 95% CI 1.27-3.08). The use of statins was not protective against the recurrence of adenomatous polyps.

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Citations

Nov 2, 2012·International Journal of Colorectal Disease·Thomas BroughtonIan L P Beales
Sep 18, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Paul Lochhead, Andrew T Chan
Apr 5, 2016·Journal of Gastroenterology and Hepatology·Yoon Suk JungDong Soo Han

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