Statin Use during Hospitalization and Short-Term Mortality in Acute Ischaemic Stroke with Chronic Kidney Disease

European Neurology
Xinmiao ZhangY Wang

Abstract

Statin use during hospitalization improves prognosis in patients with ischaemic stroke. However, it remains uncertain whether acute ischaemic stroke patients with chronic kidney disease (CKD) benefit from statin therapy. We investigated the effect of statin use during hospitalization in reducing short-term mortality of patients with ischaemic stroke and CKD. Data of first-ever ischaemic stroke patients without a history of pre-stroke statin treatment was derived from the China National Stroke Registry. Patients were stratified according to estimated glomerular filtration rate (eGFR): normal renal function (eGFR ≥90 mL/min/1.73 m2), mild CKD (eGFR 60-90 mL/min/1.73 m2) and moderate CKD (eGFR < 60 mL/min/1.73 m2). Multivariate logistic regression analysis was used to evaluate the association between statin use during hospitalization and all-cause mortality with different renal functions at 3-month follow-up. Among 5,951 patients included, 2,595 (43.6%) patients were on statin use during hospitalization after stroke (45.7% in patients with normal renal function, 42.0% in patients with mild CKD, and 39.0% in patients with moderate CKD). Compared with the non-statin group, statin use during hospitalization was associated with decrea...Continue Reading

References

Jan 17, 2003·Annals of Internal Medicine·Marcello TonelliUNKNOWN Cholesterol and Recurrent Events (CARE) Trial Investigators
Jul 16, 2003·Annals of Internal Medicine·Andrew S LeveyUNKNOWN National Kidney Foundation
Jun 3, 2004·Circulation·Julian P J Halcox, John E Deanfield
Oct 29, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Tammy M Keough-RyanCatherine M Clase
Nov 27, 2008·Kidney International. Supplement·Victoria CachofeiroJosé Luño
Feb 3, 2009·Stroke; a Journal of Cerebral Circulation·Gilad YahalomDavid Tanne
May 27, 2009·Cerebrovascular Diseases·Elizabeth MostofskyMurray A Mittleman
Oct 5, 2010·BMJ : British Medical Journal·Meng LeeBruce Ovbiagele
May 24, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Boon Wee TeoEvan J C Lee
May 26, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Yongjun WangUNKNOWN China National Stroke Registry Investigators
Jun 21, 2011·Journal of the Neurological Sciences·Manuel CappellariGiuseppe Moretto
Oct 25, 2011·Stroke; a Journal of Cerebral Circulation·Alexander C FlintS Claiborne Johnston
Jan 24, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·Hardaman K BaryanCraig J Smith
Feb 24, 2012·The American Journal of Cardiology·Sang Yup LimUNKNOWN Korea Acute Myocardial Infarction Registry Investigators
Jan 5, 2013·Stroke; a Journal of Cerebral Circulation·Danielle Ní ChróinínPeter J Kelly
May 9, 2013·Contributions to Nephrology·Suk Jae Kim, Oh Young Bang
Mar 7, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Mohamed Al-KhaledJürgen Eggers
May 3, 2014·Stroke; a Journal of Cerebral Circulation·Walter N KernanUNKNOWN American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and
Aug 15, 2014·Stroke; a Journal of Cerebral Circulation·Yang LuoUNKNOWN CNSR Investigators
Aug 26, 2014·Stroke; a Journal of Cerebral Circulation·Pierre AmarencoJustin A Zivin
Oct 31, 2014·Stroke; a Journal of Cerebral Circulation·James F MeschiaUNKNOWN Council on Hypertension
Aug 26, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Bo SongYuming Xu
Oct 7, 2015·Journal of Stroke·Keun-Sik Hong, Ji Sung Lee
Mar 26, 2016·International Journal of Stroke : Official Journal of the International Stroke Society·Yuesong PanYongjun Wang
Jun 14, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Douglas L WeeksMegan N Willson
Aug 2, 2016·The Lancet. Diabetes & Endocrinology·UNKNOWN Cholesterol Treatment Trialists' (CTT) CollaborationColin Baigent
Oct 26, 2016·Stroke; a Journal of Cerebral Circulation·Zixiao LiUNKNOWN China National Stroke Registries
Dec 25, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Kazunori ToyodaUNKNOWN J-STARS Investigators
Oct 11, 2017·Stroke and Vascular Neurology·Wenzhi WangYongjun Wang

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Citations

Sep 24, 2020·TH Open : Companion Journal to Thrombosis and Haemostasis·Carmine SiniscalchiUNKNOWN and the RIETE Investigators
May 19, 2020·Journal of Atherosclerosis and Thrombosis·Shin-Joe YehUNKNOWN and Taiwan Stroke Registry Investigators

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